Evidence map›Paper›PMID 32848582›Full record

ArticleFrontiers in neuroscience2020

Abnormal Spontaneous Neural Activity in Parkinson's Disease With "pure" Apathy.

Hai-Hua Sun, Jian-Bin Hu, Jing Chen, Xue-Yang Wang, Xiao-Li Wang, Ping-Lei Pan, Chun-Feng Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Hai-Hua SunDepartment of Neurology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, China.
Jian-Bin HuDepartment of Radiology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, China.
Jing ChenDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Xue-Yang WangDepartment of Radiology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, China.
Xiao-Li WangDepartment of Emergency, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, China.
Ping-Lei PanDepartment of Radiology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, China.
Chun-Feng LiuDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Yancheng Third People's Hospital · CNSecond Affiliated Hospital of Soochow University · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundApathy is one of the most common non-motor symptoms of Parkinson's disease (PD). However, its pathophysiology remains unclear.

methodsWe analyzed resting-state functional magnetic resonance imaging (MRI) data acquired at a 3.0T MRI scanner using the amplitude of low-frequency fluctuation (ALFF) metric in 20

resultsWe found that the ALFF decreased significantly in the bilateral nucleus accumbens, dorsal anterior cingulate cortex (ACC), and left dorsolateral prefrontal cortex in patients with PD-A compared to patients with PD-NA and HC subjects. Furthermore, apathy severity was negatively correlated with the ALFF in the bilateral nucleus accumbens and dorsal ACC in the pooled patients with PD.

conclusionThe present study characterized the functional pattern of changes in spontaneous neural activity in patients with PD-A. With the aim to better elucidate the pathophysiological mechanisms responsible for these changes, this study controlled for the potentially confounding effects of dopaminergic medication, depression, anxiety, and global cognitive impairment. The findings of the current study add to the literature by highlighting potential abnormalities in mesocorticolimbic pathways involved in the development of apathy in PD.

Indexed as

amplitude of low-frequency fluctuationapathydorsal anterior cingulate cortexnucleus accumbensParkinson’s disease

Identifiers

PMID32848582
PMCPMC7417661
OpenAlexW3047589195

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.