ArticleFrontiers in neuroscience2020
Electroencephalographic Cross-Frequency Coupling as a Sign of Disease Progression in Patients With Mild Cognitive Impairment: A Pilot Study.
Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Functional and effective EEG connectivity patterns in Alzheimer's disease and mild cognitive impairment: a systematic review.Frontiers in aging neuroscience · 2025Pooled it
- Cognitive and Neuropathophysiological Outcomes of Gamma-tACS in Dementia: A Systematic Review.Neuropsychology review · 2024Pooled it
- A qualitative exploration of 40 Hz sound and music for older adults with mild cognitive impairment.Geriatric nursing (New York, N.Y.)Trial
- State-Dependent Alterations of Hippocampal Theta-Gamma Coupling in 5xFAD Mice and Their Differential Modulation by Donepezil.Brain sciences · 2026Article
- A three-component dynamical index of consciousness-related neural organisation.Biological cybernetics · 2026Article
- Alcohol use disorder is associated with altered frontomedial phase-amplitude coupling strength during resting state.Neuroimage. Reports · 2026Article
- Wearable EEG devices in the detection of mild cognitive impairment: a systematic review.NPJ digital medicine · 2026Article
- Light-based 40 Hz sensory therapy for brain disorders: physiological basis, therapeutic mechanisms, and future prospects.Frontiers in medicine · 2026Review
- Resting-state EEG biomarkers of general and domain-specific cognitive impairment and plasma P-tau217 in patients with Alzheimer's disease and mild cognitive impairment.Frontiers in neurology · 2026Article
- γ neuromodulations: unraveling biomarkers for neurological and psychiatric disorders.Military Medical Research · 2025Review
- Exploring the neuromagnetic signatures of cognitive decline from mild cognitive impairment to Alzheimer's disease dementia.EBioMedicine · 2025Article
- Electrical brain networks before and after transcranial pulsed shockwave stimulation in Alzheimer's patients.GeroScience · 2025Article
- Cell-type-specific contributions to theta-gamma coupled rhythms in the hippocampus.Network neuroscience (Cambridge, Mass.) · 2025Article
- Encephalography cross-frequency coupling and brain alteration in amyotrophic lateral sclerosis.Brain communications · 2025Article
- How to design optimal brain stimulation to modulate phase-amplitude coupling?Journal of neural engineering · 2024Article
- Functionally annotated electrophysiological neuromarkers of healthy ageing and memory function.Human brain mapping · 2024Article
- Alzheimer's disease diagnosis using rhythmic power changes and phase differences: a low-density EEG study.Frontiers in aging neuroscience · 2024Article
- Advances in the study of cholinergic circuits in the central nervous system.Annals of clinical and translational neurology · 2023Review
- Toward the Identification of Neurophysiological Biomarkers for Alzheimer's Disease in Down Syndrome: A Potential Role for Cross-Frequency Phase-Amplitude Coupling Analysis.Aging and disease · 2023Review
- Neuroprosthetics: from sensorimotor to cognitive disorders.Communications biology · 2023Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mild cognitive impairment (MCI) refers to mild objective cognitive deficits and is associated with the later development of Alzheimer's disease (AD). However, not all patients with MCI convert to AD. EEG spectral power has shown promise as a marker of progression, but brain oscillations in different frequencies are not isolated entities. Coupling between different frequency bands, so-called cross-frequency coupling (CFC), has been associated with memory function and may further contribute to our understanding of what characterizes patients with MCI who progress to AD. In the current study, we wanted to investigate the changes in gamma/theta CFC in patients with AD and MCI compared to HC and in patients with pMCI compared to patients with sMCI. Furthermore, we wanted to investigate the association with cognitive test scores. EEGs were included at baseline for 15 patients with AD, 25 patients with MCI, and 36 older HC, and the participants were followed for up to 3 years. To investigate CFC, we calculated the modulation index (MI), which has been shown to be less affected by noisy data compared to other techniques. We found that patients with pMCI showed a significantly lower global gamma/theta CFC compared to patients with sMCI. In addition, global gamma/theta CFC was significantly correlated with Addenbrooke's Cognitive Examination (ACE) score (
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