ReviewFrontiers in neuroscience2020
Assessment of Long-Term Effects of Sports-Related Concussions: Biological Mechanisms and Exosomal Biomarkers.
Review in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Engaging Teenage Grassroots Soccer Players in Sports-Related Concussion Education.Health expectations : an international journal of public participation in health care and health policy · 2026Article
- Perceptual Decision Efficiency and Optimal Sleep Quality Are Associated with Female College Soccer Injury Avoidance.Brain sciences · 2026Article
- Intraindividual Variability in Perceptual-Motor Performance Measured with Virtual Reality Among Military Veterans.Brain sciences · 2026Article
- Sex differences in memory impairments after traumatic brain injury: mechanisms and models.Frontiers in behavioral neuroscience · 2026Review
- Differential Neuroendocrine Responses and Dysregulation of the Hypothalamic-Pituitary-Adrenal Axis Following Repeated Mild Concussive Impacts and Blast Exposures in a Rat Model.Brain sciences · 2025Article
- Remote photobiomodulation ameliorates behavioral and neuropathological outcomes in a rat model of repeated closed head injury.Translational psychiatry · 2025Article
- Reduction of inflammatory biomarkers underlies extracellular vesicle mediated functional recovery in an aged monkey model of cortical injury.Frontiers in aging neuroscience · 2025Article
- A Comparative Neuroimaging Review of Repetitive Head Impacts and Mild Traumatic Brain Injury from Pediatrics to Professionals.Neurotrauma reports · 2025Review
- The Effect of Intranasal Plus Transcranial Photobiomodulation on Neuromuscular Control in Individuals with Repetitive Head Acceleration Events.Photobiomodulation, photomedicine, and laser surgery · 2024Article
- Analysis of Player Performance and Financial Costs Associated With Implementation of an Updated National Hockey League Concussion Protocol: A Retrospective Comparative Study.Orthopaedic journal of sports medicine · 2024Article
- Strain in the Midbrain: Impact of Traumatic Brain Injury on the Central Serotonin System.Brain sciences · 2024Review
- Exploring psychedelic use in athletes and their attitudes toward psilocybin-assisted therapy in concussion recovery.Therapeutic advances in psychopharmacology · 2024Article
- Concussion history and virtual reality metrics predict core or lower extremity injury occurrence among high school athletes.Frontiers in sports and active living · 2024Article
- Clinical Theragnostic Signature of Extracellular Vesicles in Traumatic Brain Injury (TBI).ACS chemical neuroscience · 2023Review
- Acute Treatment with the M-Channel (KNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- Subtle impairments of perceptual-motor function and well-being are detectable among military cadets and college athletes with self-reported history of concussion.Frontiers in sports and active living · 2023Article
- Tau as a fluid biomarker of concussion and neurodegeneration.Concussion (London, England) · 2022Review
- Altered Serotonin 2A (5-HTFrontiers in pharmacology · 2022Article
- Perceptual-Motor Efficiency and Concussion History Are Prospectively Associated With Injury Occurrences Among High School and Collegiate American Football Players.Orthopaedic journal of sports medicine · 2021Article
- Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
Concussion or mild traumatic brain injury (mTBI) in athletes can cause persistent symptoms, known as post-concussion syndrome (PCS), and repeated injuries may increase the long-term risk for an athlete to develop neurodegenerative diseases such as chronic traumatic encephalopathy (CTE), and Alzheimer's disease (AD). The Center for Disease Control estimates that up to 3.8 million sport-related mTBI are reported each year in the United States. Despite the magnitude of the phenomenon, there is a current lack of comprehensive prognostic indicators and research has shown that available monitoring tools are moderately sensitive to short-term concussion effects but less sensitive to long-term consequences. The overall aim of this review is to discuss novel, quantitative, and objective measurements that can predict long-term outcomes following repeated sports-related mTBIs. The specific objectives were (1) to provide an overview of the current clinical and biomechanical tools available to health practitioners to ensure recovery after mTBIs, (2) to synthesize potential biological mechanisms in animal models underlying the long-term adverse consequences of mTBIs, (3) to discuss the possible link between repeated mTBI and neurodegenerative diseases, and (4) to discuss the current knowledge about fluid biomarkers for mTBIs with a focus on novel exosomal biomarkers. The conclusions from this review are that current post-concussion clinical tests are not sufficiently sensitive to injury and do not accurately quantify post-concussion alterations associated with repeated mTBIs. In the current review, it is proposed that current practices should be amended to include a repeated symptom inventory, a cognitive assessment of executive function and impulse control, an instrumented assessment of balance, vestibulo-ocular assessments, and an improved panel of blood or exosome biomarkers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.