ArticleNeuropsychiatric disease and treatment2020
Association Between IL-6 and Seizure Recurrence in Patients with the First Post-Ischemic Stroke Seizure.
Article in Neuropsychiatric disease and treatment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Outcomes of patients with post-stroke epilepsy: A scoping review on quality of life, readmissions, costs, seizure recurrence, and medication adherence.Epilepsia open · 2026Review
- Association Between Multiple Inflammation-Derived Indices and the Risk of Post-Stroke Epilepsy.CNS neuroscience & therapeutics · 2026Article
- Characterizing inflammatory biomarkers in post-stroke seizure risk and outcome prognostication.PloS one · 2026Article
- Neuroprotection and activation of anti-inflammatory and plasticity mechanisms by PLC-β inhibition after cholinergic hyperstimulation in hippocampal slices and microglial cells.IBRO neuroscience reports · 2025Article
- Refractory Status Epilepticus and Therapeutic Uncertainties: a Comprehensive Review on Targeting Neuroinflammation and Rationale for Developing a Platform Trial.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Risk factors of posthemorrhagic seizure in spontaneous intracerebral hemorrhage.Neurosurgical review · 2025Article
- Optimization of seizure prevention by cannabidiol (CBD).Translational neuroscience · 2025Article
- IL-6 is associated with poor seizure control in low-grade glioma patients undergoing primary resection.iScience · 2024Article
- Poststroke Seizure and Epilepsy: A Review of Incidence, Risk Factors, Diagnosis, Pathophysiology, and Pharmacological Therapies.Oxidative medicine and cellular longevity · 2022Review
- Mechanism of Sanhua Decoction in the Treatment of Ischemic Stroke Based on Network Pharmacology Methods and Experimental Verification.BioMed research international · 2022Article
- Serum Interleukin-37 Increases in Patients after Ischemic Stroke and Is Associated with Stroke Recurrence.Oxidative medicine and cellular longevity · 2021Article
- Advances in the Development of Biomarkers for Poststroke Epilepsy.BioMed research international · 2021Review
- The role of miR-10b-5p/brain-derived neurotrophic factor axis deregulation in poststroke epileptogenesis.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo study the association between IL-6 level and seizure recurrence in patients with the first post-ischemic stroke seizure and assess its predictive value for seizure recurrence. PATIENTS AND
methodsA total of 2976 consecutive ischemic stroke patients were retrospectively enrolled. Among them, 209 (7.02%) patients with the first post-ischemic stroke seizure were included in this analysis. The IL-6 mRNA expression level was evaluated through quantitative real-time PCR (qRT-PCR) and the 2
resultsAmong the patients included, 105 (50.24%) had recurrence of seizures, and 104 (49.76%) had no recurrence. Multivariate analysis demonstrated that the IL-6 mRNA expression level was independently correlated with seizure recurrence in patients with the first post-ischemic stroke seizure after adjusting for age, NIHSS scores, time of seizure, seizure type, lesion size, location of the offending lesion to different hemispheric lobes, cortical involvement, gender, electroencephalography (EEG) findings, and hemorrhagic transformation. When the IL-6 mRNA expression level was used to predict seizure recurrence, the area under the ROC curve (AUC) was 0.763 (SE=0.033, 95% CI=0.698-0.829). The diagnostic power was moderate.
conclusionIL-6 was independently correlated with seizure recurrence in patients with the first post-ischemic stroke seizure and might be a potential biomarker for prediction of seizure recurrence.
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