ArticleInternational journal of chronic obstructive pulmonary disease2020
Frailty in Chronic Obstructive Pulmonary Disease and Risk of Exacerbations and Hospitalizations.
Article in International journal of chronic obstructive pulmonary disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 7 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 7 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- The impact of frailty on clinical outcomes among individuals with COPD: a systematic review and meta-analysis.BMC pulmonary medicine · 2025Pooled it
- Frailty in COPD: Clinical Impact, Diagnosis, Biomarkers, and Management Strategies.International journal of chronic obstructive pulmonary disease · 2025Pooled it
- Guideline
- Frailty and its influence on mortality and morbidity in COPD: A Systematic Review and Meta-Analysis.Internal and emergency medicine · 2023Pooled it
- Prevalence and risk factors of frailty in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis.European geriatric medicine · 2023Pooled it
- Prevalence and clinical impact of frailty in COPD: a systematic review and meta-analysis.BMC pulmonary medicine · 2023Pooled it
- Systematic review and meta-analysis of prevalence, trajectories, and clinical outcomes for frailty in COPD.NPJ primary care respiratory medicine · 2023Pooled it
- Frailty in Pulmonary Arterial Hypertension: A Cohort Study.Annals of the American Thoracic Society · 2026Article
- Nonlinear thresholds in lipid-frailty interplay: Precision targets for severe airflow limitation in aging adults.PloS one · 2026Article
- Article
- Joint association of frailty index and biological age with chronic obstructive pulmonary disease: a cohort study from CHARLS.Scientific reports · 2025Article
- Advances in pathophysiology and assessment methods of chronic obstructive pulmonary disease with frailty.Chinese medical journal pulmonary and critical care medicine · 2025Review
- Is meeting 24-hour movement guidelines associated with a lower risk of frailty among adults?The international journal of behavioral nutrition and physical activity · 2025Article
- Association of Patient-Reported Outcome Patterns and Major Clinical Factors with Frailty in Stable COPD.International journal of chronic obstructive pulmonary disease · 2025Article
- Characteristics, Treatment, and Prognosis of Heart Failure Patients with Chronic Obstructive Pulmonary Disease in the Colombian Heart Failure Registry (RECOLFACA).Journal of cardiovascular development and disease · 2024Article
- Extracellular Water Ratio and Phase Angle as Predictors of Exacerbation in Chronic Obstructive Pulmonary Disease.Advances in respiratory medicine · 2024Article
- Olfactory decline develops in parallel with frailty in older US adults with obstructive lung diseases.International forum of allergy & rhinology · 2024Article
- Association between oxidative balance score and frailty in chronic obstructive pulmonary disease.Heliyon · 2024Article
- Impact of Frailty on Symptom Burden in Chronic Obstructive Pulmonary Disease.Journal of clinical medicine · 2024Review
- The Long-Term Impact of Frailty After an Intensive Care Unit Admission Due to Chronic Obstructive Pulmonary Disease.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2024Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Frailty is a complex clinical syndrome associated with vulnerability to adverse health outcomes. While frailty is thought to be common in chronic obstructive pulmonary disease (COPD), the relationship between frailty and COPD-related outcomes such as risk of acute exacerbations of COPD (AE-COPD) and hospitalizations is unclear. Purpose: To examine the association between physical frailty and risk of acute exacerbations, hospitalizations, and mortality in patients with COPD. Methods: A longitudinal analysis of data from a cohort of 280 participants was performed. Baseline frailty measures included exhaustion, weakness, low activity, slowness, and undernutrition. Outcome measures included AE-COPD, hospitalizations, and mortality over 2 years. Negative binomial regression and Cox proportional hazard modeling were used. Results: Sixty-two percent of the study population met criteria for pre-frail and 23% were frail. In adjusted analyses, the frailty syndrome was not associated with COPD exacerbations. However, among the individual components of the frailty syndrome, weakness measured by handgrip strength was associated with increased risk of COPD exacerbations (IRR 1.46, 95% CI 1.09-1.97). The frailty phenotype was not associated with all-cause hospitalizations but was associated with increased risk of non-COPD-related hospitalizations. Conclusion: This longitudinal cohort study shows that a high proportion of patients with COPD are pre-frail or frail. The frailty phenotype was associated with an increased risk of non-COPD hospitalizations but not with all-cause hospitalizations or COPD exacerbations. Among the individual frailty components, low handgrip strength was associated with increased risk of COPD exacerbations over a 2-year period. Measuring handgrip strength may identify COPD patients who could benefit from programs to reduce COPD exacerbations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.