Trial reportClinical interventions in aging2020
The Effect of Mindfulness-Based Stress Reduction (MBSR) on Depression, Cognition, and Immunity in Mild Cognitive Impairment: A Pilot Feasibility Study.
Trial report in Clinical interventions in aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Meditation for subjective cognitive decline, mild cognitive impairment and Alzheimer's disease: a systematic review and meta-analysis of randomized controlled trials.Frontiers in public health · 2025Pooled it
- Only Small Effects of Mindfulness-Based Interventions on Biomarker Levels of Inflammation and Stress: A Preregistered Systematic Review and Two Three-Level Meta-Analyses.International journal of molecular sciences · 2023Pooled it
- Psychological treatments for depression and anxiety in dementia and mild cognitive impairment.The Cochrane database of systematic reviews · 2022Pooled it
- Trial
- Mindfulness-Based Stress Reduction for Symptom Management in Older Individuals with HIV-Associated Neurocognitive Disorder.AIDS and behavior · 2024Trial
- Effect of mindfulness-based stress reduction (MBSR) program on depression, emotion regulation, and sleep problems: A randomized controlled trial study on depressed elderly.BMC public health · 2024Trial
- Trial
- Evidence-Based Strategies for Addressing Cancer- and Treatment-Related Cognitive Impairment: A Review.Biomolecules & therapeutics · 2026Review
- Optimal doses of mind-body exercise on neuroinflammation in individuals with neuropsychiatric disorders: A systematic review and dose-response meta-analysis.Brain, behavior, & immunity - health · 2026Article
- Mindfulness-based stress reduction combined with reminiscence therapy: a non-pharmacological approach for older adults with mild cognitive impairment or mild dementia due to Alzheimer's disease.Frontiers in aging neuroscience · 2026Article
- Impact of Face-to-Face and Online Mindfulness-Based Public Health Interventions on Health-Related Quality of Life in Older People: A Comparative Study.International journal of environmental research and public health · 2025Article
- From triple-mode network to triple-layered model - novel insights in social cognition.Indian journal of psychiatry · 2025Article
- Mindfulness, cognitive load, and performance: examining the interplay of stress and self-regulation in physical education.BMC psychology · 2025Article
- Effects of Mind-Body Interventions on Immune and Neuroendocrine Functions: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Healthcare (Basel, Switzerland) · 2025Review
- Mindfulness-Based Cognitive Therapy in Clinical Practice: A Systematic Review of Neurocognitive Outcomes and Applications for Mental Health and Well-Being.Journal of clinical medicine · 2025Review
- Online mindfulness meditation for mild cognitive impairment and mild dementia: A feasibility study protocol.PloS one · 2025Article
- Effect of online modified mindfulness-based stress reduction training on the resilience of nursing interns in China.Nursing open · 2023Article
- Article
- Effects of Mind-Body Training as a Mental Health Therapy in Adults with Diabetes Mellitus Type II: A Systematic Review.Journal of clinical medicine · 2023Review
- Anxiety disorder in menopausal women and the intervention efficacy of mindfulness-based stress reduction.American journal of translational research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMindfulness-based programs have shown a promising effect on several health factors associated with increased risk of dementia and the conversion from mild cognitive impairment (MCI) to dementia such as depression, stress, cognitive decline, immune system and brain structural and functional changes. Studies on mindfulness in MCI subjects are sparse and frequently lack control intervention groups.
objectiveTo determine the feasibility and the effect of mindfulness-based stress reduction (MBSR) practice on depression, cognition and immunity in MCI compared to cognitive training.
methodsTwenty-eight MCI subjects were randomly assigned to two groups. MBSR group underwent 8-week MBSR program. Control group underwent 8-week cognitive training. Their cognitive and immunological profiles and level of depressive symptoms were examined at baseline, after each 8-week intervention (visit 2, V2) and six months after each intervention (visit 3, V3). MBSR participants completed feasibility questionnaire at V2.
resultsTwenty MCI patients completed the study (MBSR group n=12, control group n=8). MBSR group showed significant reduction in depressive symptoms at both V2 (p=0.03) and V3 (p=0.0461) compared to the baseline. There was a minimal effect on cognition - a group comparison analysis showed better psychomotor speed in the MBSR group compared to the control group at V2 (p=0.0493) but not at V3. There was a detectable change in immunological profiles in both groups, more pronounced in the MBSR group. Participants checked only positive/neutral answers concerning the attractivity/length of MBSR intervention. More severe cognitive decline (PVLT≤36) was associated with the lower adherence to home practice.
conclusionMBSR is well-accepted potentially promising intervention with positive effect on cognition, depressive symptoms and immunological profile.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.