Evidence map›Paper›PMID 32848220›Full record

ArticleNature2020

Heterotypic cell-cell communication regulates glandular stem cell multipotency.

Alessia Centonze, Shuheng Lin, Elisavet Tika, Alejandro Sifrim, Marco Fioramonti, Milan Malfait, Yura Song, Aline Wuidart, Jens Van Herck, Anne Dannau and 9 more

Open access · greenAbstract read
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 139 citations in OpenAlex.

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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 3 countries.

Alessia Centonze *Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Shuheng Lin *Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Elisavet TikaLaboratory of Stem Cells and Cancer, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Alejandro SifrimDepartment of Human Genetics, University of Leuven, KU Leuven, Leuven, Belgium.
Marco FioramontiLaboratory of Stem Cells and Cancer, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Milan MalfaitLaboratory of Stem Cells and Cancer, Université Libre de Bruxelles (ULB), Brussels, Belgium.ORCID http://orcid.org/0000-0001-9144-3701
Yura SongLaboratory of Stem Cells and Cancer, Université Libre de Bruxelles (ULB), Brussels, Belgium.ORCID http://orcid.org/0000-0002-1173-9172
Aline WuidartLaboratory of Stem Cells and Cancer, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Jens Van HerckDepartment of Human Genetics, University of Leuven, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-1291-4462
Anne DannauLaboratory of Stem Cells and Cancer, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Gaelle BouvencourtLaboratory of Stem Cells and Cancer, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Christine DuboisLaboratory of Stem Cells and Cancer, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Nina DedonckerDepartment of Human Genetics, University of Leuven, KU Leuven, Leuven, Belgium.
Amar SahayCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, USA.
Viviane de MaertelaerIRIBHM, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Christian W SiebelDepartment of Discovery Oncology, Genentech, South San Francisco, CA, USA.
Alexandra Van KeymeulenLaboratory of Stem Cells and Cancer, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Thierry VoetDepartment of Human Genetics, University of Leuven, KU Leuven, Leuven, Belgium.
Cédric BlanpainLaboratory of Stem Cells and Cancer, Université Libre de Bruxelles (ULB), Brussels, Belgium. cedric.blanpain@ulb.ac.be.ORCID http://orcid.org/0000-0002-4028-4322
Université Libre de Bruxelles · BEKU Leuven · BEWellcome Sanger Institute · GBBroad Institute · US

Funding

European Research Council 616333
6 · The paper itself

Abstract

Glandular epithelia, including the mammary and prostate glands, are composed of basal cells (BCs) and luminal cells (LCs)

Indexed as

Cell CommunicationAnimalsCell LineageEpithelial CellsErbB ReceptorsFemaleHomeostasisHumansMaleMammary Glands, AnimalMiceMultipotent Stem CellsOrganoidsProstateReceptors, NotchRNA, MessengerErbB ReceptorsReceptors, NotchRNA, MessengerTumor Necrosis Factor-alphaWnt Proteins

Identifiers

PMID32848220
PMCPMC7116172
OpenAlexW3081224187

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.