Evidence map›Paper›PMID 32848206›Full record

ReviewNature reviews. Nephrology2020

Digital pathology and computational image analysis in nephropathology.

Laura Barisoni, Kyle J Lafata, Stephen M Hewitt, Anant Madabhushi, Ulysses G J Balis

Open access · bronzeAbstract readReview
In one paragraph

Review in Nature reviews. Nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed, 2 pooled it
19.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 2 syntheses or guidelines pooled it, 249 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  7. Review
  8. [Histology and more-modern nephropathology].Innere Medizin (Heidelberg, Germany) · 2026
    Review
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70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Laura BarisoniDepartment of Pathology, Duke University, Durham, NC, USA. laura.barisoni@duke.edu.ORCID http://orcid.org/0000-0003-0848-9683
Kyle J LafataDepartment of Radiology, Duke University, Durham, NC, USA.
Stephen M HewittLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Anant MadabhushiDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Ulysses G J BalisDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-4168-1477
Duke University · USLouis Stokes Cleveland VA Medical Center · USNational Cancer Institute · USUniversity of Michigan · US

Funding

Central Hub for Kidney Precision MedicineU24DK114886 · NIDDK · UNIVERSITY OF WASHINGTON · PI Jonathan Himmelfarb, Matthias Kretzler · 2022 to 2026
$21.1M
ConProject-002U2CDK114886 · NIDDK · UNIVERSITY OF WASHINGTON · PI HIMMELFARB, JONATHAN, IYENGAR, SRINIVAS RAVI V · 2017 to 2021
$21.0M
Training Program in Clinical & Translationa Research in Human Glomerular DiseaseU54DK083912 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GIPSON, DEBBIE S · 2009 to 2023
$20.3M
GDPrimeUM1DK100845 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GIPSON, DEBBIE S, KRETZLER, MATTHIAS · 2013 to 2018
$6.4M
Computational Pathology of Proteinuric DiseasesR01DK118431 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BARISONI, LAURA MARIACHIARA, HODGIN, JEFFREY BENTON · 2018 to 2025
$3.6M
APOL1 - associated nephropathy from human-derived, intrarenal perspectiveR01DK108805 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MATTHEW Gordon SAMPSON, Simone Sanna-Cherchi · 2016 to 2026
$3.4M
Computerized histologic image predictor of cancer outcomeR01CA202752 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI FELDMAN, MICHAEL D, GANESAN, SHRIDAR · 2016 to 2020
$3.1M
Quantitative Histomorphometric Risk Classifier (QuHbIC) in HPV + Oropharyngeal CarcinomaR01CA220581 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI KOYFMAN, SHLOMO, LEWIS, JAMES · 2018 to 2023
$3.1M
Computerized Histologic Risk Predictor (CHiRP) for Early Stage Lung CancersR01CA216579 · NCI · EMORY UNIVERSITY · PI FU, PINGFU, LLOYD, MARK · 2018 to 2023
$3.1M
MR Fingerprinting and Computerized Decision Support for Prostate CancerR01CA208236 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GULANI, VIKAS, PONSKY, LEE EVAN · 2017 to 2022
$3.0M
Pathology Image Informatics Platform for visualization, analysis and managementU24CA199374 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI GURCAN, METIN NAFI, MADABHUSHI, ANANT · 2015 to 2019
$2.9M
HistoTools: A suite of digital pathology tools for quality control, annotation and dataset identificationU01CA239055 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI JANOWCZYK, ANDREW ROBERT, MADABHUSHI, ANANT · 2019 to 2022
$1.0M
BLRD VA I01 BX004121NCI NIH HHS 1U01 CA239055-01NCI NIH HHS CA220581-01A1NCI NIH HHS R01 CA202752NCI NIH HHS R01 CA208236NCI NIH HHS R01CA208236-01A1NCI NIH HHS R01 CA216579NCI NIH HHS R01 CA216579-01A1NCI NIH HHS R01 CA220581NCI NIH HHS U01 CA239055NCI NIH HHS U24 CA199374NCRR NIH HHS C06 RR012463NCRR NIH HHS C06 RR12463-01NIBIB NIH HHS 1R43EB028736-01NIBIB NIH HHS R43 EB028736NIDDK NIH HHS 1RC2DK01NIDDK NIH HHS R01 DK108805NIDDK NIH HHS R01 DK118431NIDDK NIH HHS U24 DK114886NIDDK NIH HHS U2C DK114886NIDDK NIH HHS U54 DK083912NIDDK NIH HHS UH3 DK114908NIDDK NIH HHS UM1 DK100845
6 · The paper itself

Abstract

The emergence of digital pathology - an image-based environment for the acquisition, management and interpretation of pathology information supported by computational techniques for data extraction and analysis - is changing the pathology ecosystem. In particular, by virtue of our new-found ability to generate and curate digital libraries, the field of machine vision can now be effectively applied to histopathological subject matter by individuals who do not have deep expertise in machine vision techniques. Although these novel approaches have already advanced the detection, classification, and prognostication of diseases in the fields of radiology and oncology, renal pathology is just entering the digital era, with the establishment of consortia and digital pathology repositories for the collection, analysis and integration of pathology data with other domains. The development of machine-learning approaches for the extraction of information from image data, allows for tissue interrogation in a way that was not previously possible. The application of these novel tools are placing pathology centre stage in the process of defining new, integrated, biologically and clinically homogeneous disease categories, to identify patients at risk of progression, and shifting current paradigms for the treatment and prevention of kidney diseases.

Indexed as

Precision MedicineHumansImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedKidney DiseasesMachine LearningNephrology

Identifiers

PMID32848206
PMCPMC7447970
OpenAlexW3080446999

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.