Evidence map›Paper›PMID 32848204›Full record

ArticleMolecular psychiatry2021

Serotonin transporter availability in adults with autism-a positron emission tomography study.

Max Andersson, Ämma Tangen, Lars Farde, Sven Bölte, Christer Halldin, Jacqueline Borg, Johan Lundberg

Open access · hybridAbstract read
In one paragraph

Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
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  11. Therapeutic effects ofFrontiers in pharmacology · 2025
    Article
  12. Review
  13. In vivo translocator protein in females with autism spectrum disorder: a pilot study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Max AnderssonDepartment of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Region Stockholm, Stockholm, Sweden. max.andersson@ki.se.ORCID http://orcid.org/0000-0003-0024-6388
Ämma TangenDepartment of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Region Stockholm, Stockholm, Sweden.
Lars FardeDepartment of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Region Stockholm, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-1297-0816
Sven BölteDepartment of Women's and Children's Health, Karolinska Institutet, Center of Neurodevelopmental Disorders (KIND), Center for Psychiatry Research, Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-4579-4970
Christer HalldinDepartment of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Region Stockholm, Stockholm, Sweden.
Jacqueline Borg *Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Region Stockholm, Stockholm, Sweden.
Johan Lundberg *Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Region Stockholm, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-4298-3936
Karolinska Institutet · SECurtin University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Impairments in social interaction and communication, in combination with restricted, repetitive behaviors and interests, define the neurodevelopmental diagnosis of autism spectrum disorder (ASD). The biological underpinnings of ASD are not well known, but the hypothesis of serotonin (5-HT) involvement in the neurodevelopment of ASD is one of the longest standing. Reuptake through the 5-HT transporter (5-HTT) is the main pathway decreasing extracellular 5-HT in the brain and a marker for the 5-HT system, but in vivo investigations of the 5-HTT and the 5-HT system in ASD are scarce and so far inconclusive. To quantify possible alterations in the 5-HT system in ASD, we used positron emission tomography and the radioligand [

Indexed as

Autism Spectrum DisorderAutistic DisorderAdultBrainHumansPositron-Emission TomographySerotonin Plasma Membrane Transport ProteinsSerotonin Plasma Membrane Transport ProteinsSLC6A4 protein, human

Identifiers

PMID32848204
PMCPMC8159737
OpenAlexW3081060861

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.