Evidence map›Paper›PMID 32848194›Full record

ArticleScientific reports2020

Improved locomotor recovery after contusive spinal cord injury in Bmal1

Lukasz P Slomnicki, Scott A Myers, Sujata Saraswat Ohri, Molly V Parsh, Kariena R Andres, Julia H Chariker, Eric C Rouchka, Scott R Whittemore, Michal Hetman

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
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  20. Quantifying Vascular Remodeling in the Mouse Spinal Cord.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lukasz P Slomnicki *Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, 40202, USA.
Scott A Myers *Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, 40202, USA.
Sujata Saraswat Ohri *Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, 40202, USA. sujata.saraswat@louisville.edu.
Molly V ParshKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, 40202, USA.
Kariena R AndresKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, 40202, USA.
Julia H CharikerDepartment of Computer Engineering and Computer Science, University of Louisville, Louisville, KY, 40202, USA.
Eric C RouchkaDepartment of Computer Engineering and Computer Science, University of Louisville, Louisville, KY, 40202, USA.
Scott R WhittemoreKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, 40202, USA.
Michal HetmanKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, 40202, USA. michal.hetman@louisville.edu.
Neurological Surgery · USUniversity of Louisville · US

Funding

WKU Lead Faculty AwardP20GM103436 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ERIC C ROUCHKA · 2012 to 2026
$60.1M
PILOT PROJECT PROGRAMP30GM106396 · NIGMS · UNIVERSITY OF LOUISVILLE · PI MILLER, DONALD M. · 2013 to 2017
$5.4M
The integrated stress response and oligodendrocyte survival after spinal cord injuryR01NS108529 · NINDS · UNIVERSITY OF LOUISVILLE · PI HETMAN, MICHAL · 2018 to 2022
$2.7M
NIGMS NIH HHS P20 GM103436NIGMS NIH HHS P30 GM106396NINDS NIH HHS R01 NS108529
6 · The paper itself

Abstract

The transcription factor BMAL1/ARNTL is a non-redundant component of the clock pathway that regulates circadian oscillations of gene expression. Loss of BMAL1 perturbs organismal homeostasis and usually exacerbates pathological responses to many types of insults by enhancing oxidative stress and inflammation. Surprisingly, we observed improved locomotor recovery and spinal cord white matter sparing in Bmal1

Indexed as

Recovery of FunctionAnimalsARNTL Transcription FactorsLocomotionMice, Inbred C57BLMice, KnockoutSpinal Cord InjuriesTranscriptomeARNTL Transcription FactorsBmal1 protein, mouse

Identifiers

PMID32848194
PMCPMC7450087
OpenAlexW3080540572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.