ArticleScientific reports2020
Optical percutaneous needle biopsy of the liver: a pilot animal and clinical study.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 47 citations in OpenAlex.
- Early Postmortem Changes in NADH Fluorescence Lifetime Parameters in Rat Skeletal Muscle: Potential for Postmortem Interval Estimation.International journal of molecular sciences · 2026Article
- Diffuse reflectance spectroscopy for enhanced diagnostic precision in breast cancer.Journal of translational medicine · 2025Article
- Toward handheld optically guided biopsy combining diffuse reflectance spectroscopy and autofluorescence.Journal of biomedical optics · 2025Article
- Robotic Laser Tissue Soldering for Atraumatic Soft Tissue Fusion Guided by Fluorescent Nanothermometry.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Integrating Tumor Hypoxic Sensing and Photothermal Therapy Using a Miniaturized Fiber-Optic Theranostic Probe.Small science · 2025Article
- In Vivo Time-Resolved Fluorescence Detection of Liver Cancer Supported by Machine Learning.Lasers in surgery and medicine · 2024Article
- Dual-mode OCT/fluorescence system for monitoring the morphology and metabolism of laser-printed 3D full-thickness skin equivalents.Biomedical optics express · 2024Article
- Multimodal fiber probe for simultaneous mid-infrared and Raman spectroscopy.Scientific reports · 2024Article
- Biomedical Photonics Methods in Solving Diagnostic Tasks.Biomedical engineering · 2023Article
- Silicon Photomultiplier-A High Dynamic Range, High Sensitivity Sensor for Bio-Photonics Applications.Biosensors · 2022Article
- Fluorescence lifetime needle optical biopsy discriminates hepatocellular carcinoma.Biomedical optics express · 2022Article
- On the flexible needle insertion into the human liver.Scientific reports · 2021Article
- Machine Learning Aided Photonic Diagnostic System for Minimally Invasive Optically Guided Surgery in the Hepatoduodenal Area.Diagnostics (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper presents the results of the experiments which were performed using the optical biopsy system specially developed for in vivo tissue classification during the percutaneous needle biopsy (PNB) of the liver. The proposed system includes an optical probe of small diameter acceptable for use in the PNB of the liver. The results of the feasibility studies and actual tests on laboratory mice with inoculated hepatocellular carcinoma and in clinical conditions on patients with liver tumors are presented and discussed. Monte Carlo simulations were carried out to assess the diagnostic volume and to trace the sensing depth. Fluorescence and diffuse reflectance spectroscopy measurements were used to monitor metabolic and morphological changes in tissues. The tissue oxygen saturation was evaluated using a recently developed approach to neural network fitting of diffuse reflectance spectra. The Support Vector Machine Classification was applied to identify intact liver and tumor tissues. Analysis of the obtained results shows the high sensitivity and specificity of the proposed multimodal method. This approach allows to obtain information before the tissue sample is taken, which makes it possible to significantly reduce the number of false-negative biopsies.
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