Evidence map›Paper›PMID 32848149›Full record

ArticleScientific reports2020

Nanoscale mechanisms in age-related hip-fractures.

Shaocheng Ma, En Lin Goh, Tabitha Tay, Crispin C Wiles, Oliver Boughton, John H Churchwell, Yong Wu, Angelo Karunaratne, Rajarshi Bhattacharya, Nick Terrill and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. The Impact of Ageing on Fibrillar Collagens.Sub-cellular biochemistry · 2026
    Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Shaocheng MaDepartment of Mechanical Engineering, Faculty of Engineering, Imperial College London, London, SW7 2AZ, UK.
En Lin GohMSk Laboratory, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, W6 8PR, UK.
Tabitha TayMSk Laboratory, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, W6 8PR, UK.
Crispin C WilesMSk Laboratory, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, W6 8PR, UK.
Oliver BoughtonMSk Laboratory, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, W6 8PR, UK.
John H ChurchwellDepartment of Medical Physics and Biomedical Engineering, University College London, London, WCIE 6BT, UK.
Yong WuCentre for Medicine, University of Leicester Medical School, Leicester, LE1 7HA, UK.
Angelo KarunaratneDepartment of Mechanical Engineering, Faculty of Engineering, University of Moratuwa, Moratuwa, 10400, Sri Lanka.
Rajarshi BhattacharyaSt. Mary's Hospital, North West London Major Trauma Centre, Imperial College, London, W2 1NY, UK.
Nick TerrillDiamond Light Source, Diamond House, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.
Justin P CobbMSk Laboratory, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, W6 8PR, UK.
Ulrich Hansen *Department of Mechanical Engineering, Faculty of Engineering, Imperial College London, London, SW7 2AZ, UK.
Richard L Abel *MSk Laboratory, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, W6 8PR, UK. richard.abel@imperial.ac.uk.
Imperial College London · GBDiamond Light Source · GBSt Mary's Hospital · GBUniversity College London · GBUniversity of Leicester · GBUniversity of Moratuwa · LK

Funding

The Dunhill Medical Trust DMT/RCS602
6 · The paper itself

Abstract

Nanoscale mineralized collagen fibrils may be important determinants of whole-bone mechanical properties and contribute to the risk of age-related fractures. In a cross-sectional study nano- and tissue-level mechanics were compared across trabecular sections from the proximal femora of three groups (n = 10 each): ageing non-fractured donors (Controls); untreated fracture patients (Fx-Untreated); bisphosphonate-treated fracture patients (Fx-BisTreated). Collagen fibril, mineral and tissue mechanics were measured using synchrotron X-Ray diffraction of bone sections under load. Mechanical data were compared across groups, and tissue-level data were regressed against nano. Compared to controls fracture patients exhibited significantly lower critical tissue strain, max strain and normalized strength, with lower peak fibril and mineral strain. Bisphosphonate-treated exhibited the lowest properties. In all three groups, peak mineral strain coincided with maximum tissue strength (i.e. ultimate stress), whilst peak fibril strain occurred afterwards (i.e. higher tissue strain). Tissue strain and strength were positively and strongly correlated with peak fibril and mineral strains. Age-related fractures were associated with lower peak fibril and mineral strain irrespective of treatment. Indicating earlier mineral disengagement and the subsequent onset of fibril sliding is one of the key mechanisms leading to fracture. Treatments for fragility should target collagen-mineral interactions to restore nano-scale strain to that of healthy bone.

Indexed as

AgedAged, 80 and overAgingBone and BonesCase-Control StudiesCross-Sectional StudiesFemaleFibrillar CollagensHip FracturesHumansMaleNanostructuresOsteoporosisFibrillar Collagens

Identifiers

PMID32848149
PMCPMC7450077
OpenAlexW3081277941

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.