Evidence map›Paper›PMID 32848068›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

β2 Integrins differentially regulate γδ T cell subset thymic development and peripheral maintenance.

Claire L McIntyre, Leticia Monin, Jesse C Rop, Thomas D Otto, Carl S Goodyear, Adrian C Hayday, Vicky L Morrison

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. IL-27 maintains cytotoxic Ly6CThe EMBO journal · 2024
    Article
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Claire L McIntyreInstitute of Infection, Immunity & Inflammation, University of Glasgow, G12 8TA Glasgow, United Kingdom.ORCID 0000-0003-2489-7724
Leticia MoninImmunosurveillance Laboratory, The Francis Crick Institute, NW1 1AT London, United Kingdom.ORCID 0000-0002-4951-8105
Jesse C RopInstitute of Infection, Immunity & Inflammation, University of Glasgow, G12 8TA Glasgow, United Kingdom.ORCID 0000-0003-0054-1782
Thomas D OttoInstitute of Infection, Immunity & Inflammation, University of Glasgow, G12 8TA Glasgow, United Kingdom.ORCID 0000-0002-1246-7404
Carl S GoodyearInstitute of Infection, Immunity & Inflammation, University of Glasgow, G12 8TA Glasgow, United Kingdom.
Adrian C HaydayImmunosurveillance Laboratory, The Francis Crick Institute, NW1 1AT London, United Kingdom.ORCID 0000-0002-9495-5793
Vicky L MorrisonInstitute of Infection, Immunity & Inflammation, University of Glasgow, G12 8TA Glasgow, United Kingdom; vicky.morrison@glasgow.ac.uk.
University of Glasgow · GBKing's College London · GBThe Francis Crick Institute · GB

Funding

Versus Arthritis 20848Wellcome TrustWellcome Trust 204820/Z/16/Z
6 · The paper itself

Abstract

The γδ T cells reside predominantly at barrier sites and play essential roles in immune protection against infection and cancer. Despite recent advances in the development of γδ T cell immunotherapy, our understanding of the basic biology of these cells, including how their numbers are regulated in vivo, remains poor. This is particularly true for tissue-resident γδ T cells. We have identified the β

Indexed as

CD18 AntigensIntraepithelial LymphocytesThymus GlandAnimalsHomeostasisInterleukin-17MiceMice, Inbred C57BLMice, KnockoutCD18 AntigensIl17a protein, mouseInterleukin-17immune homeostasisβ2 integrinsγδ T cells

Identifiers

PMID32848068
PMCPMC7486781
OpenAlexW3080371441

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.