ArticleProceedings of the National Academy of Sciences of the United States of America2020
The cochlear outer hair cell speed paradox.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Acbd7 is essential for preserving hair cell-mediated auditory and vestibular function.Experimental & molecular medicine · 2026Article
- Chloride binding does not influence prestin motor speed at very high frequencies in the mouse outer hair cell.Structure (London, England : 1993) · 2025Article
- Sound-evoked tonic motility of cochlear outer hair cells in mice with stereociliary defects.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- AAV-Sparcl1 promotes hair cell regeneration by increasing supporting cell plasticity.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- The cortilymph wave: Its relation to the traveling wave, auditory-nerve responses, and low-frequency downward glides.Hearing research · 2025Review
- Article
- Rate-dependent cochlear outer hair cell force generation: Models and parameter estimation.Biophysical journal · 2024Article
- Optimal Scale-Invariant Wavelet Representation and Filtering of Human Otoacoustic Emissions.Journal of the Association for Research in Otolaryngology : JARO · 2024Review
- Article
- Megahertz Sampling of Prestin (SLC26a5) Voltage-Sensor Charge Movements in Outer Hair Cell Membranes Reveals Ultrasonic Activity that May Support Electromotility and Cochlear Amplification.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The Long Outer-Hair-Cell RC Time Constant: A Feature, Not a Bug, of the Mammalian Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- The Remarkable Outer Hair Cell: Proceedings of a Symposium in Honour of W. E. Brownell.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- Prestin's fast motor kinetics is essential for mammalian cochlear amplification.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A parametric blueprint for optimum cochlear outer hair cell design.Journal of the Royal Society, Interface · 2023Article
- Of mice and chickens: Revisiting the RC time constant problem.Hearing research · 2022Review
- On the frequency response of prestin charge movement in membrane patches.Biophysical journal · 2022Article
- Analysis of outer hair cell electromechanics reveals power delivery at the upper-frequency limits of hearing.Journal of the Royal Society, Interface · 2022Article
- The Elusive Cochlear Filter: Wave Origin of Cochlear Cross-Frequency Masking.Journal of the Association for Research in Otolaryngology : JARO · 2021Article
- Cochlear outer hair cell electromotility enhances organ of Corti motion on a cycle-by-cycle basis at high frequencies in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- State dependent effects on the frequency response of prestin's real and imaginary components of nonlinear capacitance.Scientific reports · 2021Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Cochlear outer hair cells (OHCs) are among the fastest known biological motors and are essential for high-frequency hearing in mammals. It is commonly hypothesized that OHCs amplify vibrations in the cochlea through cycle-by-cycle changes in length, but recent data suggest OHCs are low-pass filtered and unable to follow high-frequency signals. The fact that OHCs are required for high-frequency hearing but appear to be throttled by slow electromotility is the "OHC speed paradox." The present report resolves this paradox and reveals origins of ultrafast OHC function and power output in the context of the cochlear load. Results demonstrate that the speed of electromotility reflects how fast the cell can extend against the load, and does not reflect the intrinsic speed of the motor element itself or the nearly instantaneous speed at which the coulomb force is transmitted. OHC power output at auditory frequencies is revealed by emergence of an imaginary nonlinear capacitance reflecting the phase of electrical charge displacement required for the motor to overcome the viscous cochlear load.
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