Evidence map›Paper›PMID 32848036›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2020

A Critical Role of CD40 and CD70 Signaling in Conventional Type 1 Dendritic Cells in Expansion and Antitumor Efficacy of Adoptively Transferred Tumor-Specific T Cells.

Takaaki Oba, Toshifumi Hoki, Takayoshi Yamauchi, Tibor Keler, Henry C Marsh, Xuefang Cao, Fumito Ito

Open access · greenAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 32 citations in OpenAlex.

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  18. NeoadjuvantCancer research · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Takaaki ObaCenter for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263.
Toshifumi HokiCenter for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263.ORCID 0000-0002-8853-4167
Takayoshi YamauchiCenter for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263.ORCID 0000-0002-5685-7658
Tibor KelerCelldex Therapeutics, Inc., Hampton, NJ 08827.
Henry C MarshCelldex Therapeutics, Inc., Hampton, NJ 08827.ORCID 0000-0001-5637-6013
Xuefang CaoDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.
Fumito ItoCenter for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263; fumito.ito@roswellpark.org.ORCID 0000-0002-6866-671X
Roswell Park Comprehensive Cancer Center · USCelldex Therapeutics (United States) · USUniversity of Maryland, Baltimore · US

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MARK G FRATTINI · 1985 to 2026
$116.6M
CD27/CD70 mediated negative regulation of inflammatory T cell responsesR01HL135325 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI CAO, XUEFANG · 2018 to 2021
$2.3M
Targeting Granzyme B to Separate GVH from GVL ResponsesR01CA184728 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI CAO, XUEFANG · 2015 to 2019
$1.9M
Adoptive Cell Therapy with Rejuvenated Antigen-Specific T CellsK08CA197966 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ITO, FUMITO · 2015 to 2019
$875k
NCI NIH HHS K08 CA197966NCI NIH HHS P30 CA016056NCI NIH HHS R01 CA184728NHLBI NIH HHS R01 HL135325
6 · The paper itself

Abstract

In vivo expansion of adoptively transferred CD8

Indexed as

AnimalsAntigens, NeoplasmBasic-Leucine Zipper Transcription FactorsCD27 LigandCD40 AntigensCD8-Positive T-LymphocytesCells, CulturedCytokinesDendritic CellsImmunotherapy, AdoptiveLymphocyte ActivationMelanomaMelanoma, ExperimentalMembrane ProteinsMiceMice, Inbred C57BLAntigens, NeoplasmBasic-Leucine Zipper Transcription FactorsCD27 LigandCD40 AntigensCytokinesflt3 ligand proteinMembrane ProteinsRepressor ProteinsSNFT protein, mouse

Identifiers

PMID32848036
PMCPMC7511447
OpenAlexW3080941761

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.