Evidence map›Paper›PMID 32848017›Full record

ArticleThe Journal of biological chemistry2020

ATG16L1 autophagy pathway regulates BAX protein levels and programmed cell death.

Fenfen Chen, Dulguun Amgalan, Richard N Kitsis, Jeffrey E Pessin, Daorong Feng

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Fenfen ChenFleischer Institute of Diabetes and Metabolism, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
Dulguun AmgalanFleischer Institute of Diabetes and Metabolism, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA.
Richard N KitsisFleischer Institute of Diabetes and Metabolism, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA; Einstein-Mount Sinai Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA; Wilf Family Cardiovascular Research Center, Albert Einstein College of Medicine, Bronx, New York, USA.
Jeffrey E PessinFleischer Institute of Diabetes and Metabolism, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA; Einstein-Mount Sinai Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA; Wilf Family Cardiovascular Research Center, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA.
Daorong FengFleischer Institute of Diabetes and Metabolism, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA. Electronic address: daorong.feng@einstein.yu.edu.
Albert Einstein College of Medicine · US

Funding

Stable Isotope and Metabolomics CoreP60DK020541 · NIDDK · YESHIVA UNIVERSITY · PI PESSIN, JEFFREY E. · 1986 to 2014
$29.8M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
REGULATION OF THE INSULIN RECEPTOR KINASER01DK033823 · NIDDK · UNIVERSITY OF IOWA · PI KURLAND, IRWIN JACK, PESSIN, JEFFREY E. · 1986 to 2022
$6.7M
Intracellular signaling by the insulin receptor kinaseR37DK033823 · NIDDK · STATE UNIVERSITY NEW YORK STONY BROOK · PI PESSIN, JEFFREY E. · 2005 to 2014
$4.2M
Molecular Mechanism of Brown Adipose Tissue RegressionR01DK128839 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI FENG, DAORONG, PESSIN, JEFFREY E. · 2021 to 2024
$2.3M
NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P60 DK020541NIDDK NIH HHS R01 DK033823NIDDK NIH HHS R01 DK128839NIDDK NIH HHS R37 DK033823
6 · The paper itself

Abstract

Previously we reported that adipocyte SNAP23 (synaptosome-associated protein of 23 kDa) deficiency blocks the activation of macroautophagy, leading to an increased abundance of BAX, a pro-death Bcl-2 family member, and activation and adipocyte cell death both

Indexed as

AnimalsApoptosisAutophagyAutophagy-Related Proteinsbcl-2-Associated X ProteinMiceNIH 3T3 CellsProtein BindingQb-SNARE ProteinsQc-SNARE ProteinsSubcellular FractionsAtg16l1 protein, mouseAutophagy-Related ProteinsBax protein, mousebcl-2-Associated X ProteinQb-SNARE ProteinsQc-SNARE ProteinsSnap23 protein, mouseadipocyteapoptosisATG16L1ATG9autophagyBAXcell deathprogrammedSNAP23SNARE proteins

Identifiers

PMID32848017
PMCPMC7606669
OpenAlexW3080415235

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.