Evidence map›Paper›PMID 32848013›Full record

ArticleJournal of neurology, neurosurgery, and psychiatry2020

Early brain biomarkers of post-traumatic seizures: initial report of the multicentre epilepsy bioinformatics study for antiepileptogenic therapy (EpiBioS4Rx) prospective study.

Evan S Lutkenhoff, Vikesh Shrestha, Jesus Ruiz Tejeda, Courtney Real, David L McArthur, Dominique Duncan, Marianna La Rocca, Rachael Garner, Arthur W Toga, Paul M Vespa and 2 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, neurosurgery, and psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Evan S LutkenhoffPsychology, University of California Los Angeles, Los Angeles, California, USA.
Vikesh ShresthaBrain Injury Research Center (BIRC), Neurosurgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA.
Jesus Ruiz TejedaBrain Injury Research Center (BIRC), Neurosurgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA.
Courtney RealBrain Injury Research Center (BIRC), Neurosurgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA.
David L McArthurBrain Injury Research Center (BIRC), Neurosurgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA.
Dominique DuncanLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Marianna La RoccaLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Rachael GarnerLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Arthur W TogaLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Paul M VespaBrain Injury Research Center (BIRC), Neurosurgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA.
Martin M MontiPsychology, University of California Los Angeles, Los Angeles, California, USA monti@psych.ucla.edu.ORCID 0000-0001-5511-3780
EpiBioS4Rx Study Group
University of California, Los Angeles · USUniversity of Southern California · US

Funding

The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Public Engagement CoreU54NS100064 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ENGEL, JEROME NONE, GALANOPOULOU, ARISTEA S · 2017 to 2021
$21.7M
NINDS NIH HHS U54 NS100064
6 · The paper itself

Abstract

backgroundTraumatic brain injury (TBI) causes early seizures and is the leading cause of post-traumatic epilepsy. We prospectively assessed structural imaging biomarkers differentiating patients who develop seizures secondary to TBI from patients who do not.

designMulticentre prospective cohort study starting in 2018. Imaging data are acquired around day 14 post-injury, detection of seizure events occurred early (within 1 week) and late (up to 90 days post-TBI).

resultsFrom a sample of 96 patients surviving moderate-to-severe TBI, we performed shape analysis of local volume deficits in subcortical areas (analysable sample: 57 patients; 35 no seizure, 14 early, 8 late) and cortical ribbon thinning (analysable sample: 46 patients; 29 no seizure, 10 early, 7 late). Right hippocampal volume deficit and inferior temporal cortex thinning demonstrated a significant effect across groups. Additionally, the degree of left frontal and temporal pole thinning, and clinical score at the time of the MRI, could differentiate patients experiencing early seizures from patients not experiencing them with 89% accuracy. CONCLUSIONS AND RELEVANCE: Although this is an initial report, these data show that specific areas of localised volume deficit, as visible on routine imaging data, are associated with the emergence of seizures after TBI.

Indexed as

AdultBrain ContusionBrain Hemorrhage, TraumaticBrain Injuries, TraumaticCerebral Cortical ThinningClinical Decision RulesComputational BiologyElectroencephalographyEpilepsy, Post-TraumaticFemaleFrontal LobeGlasgow Coma ScaleHippocampusHumansImage Processing, Computer-AssistedLogistic ModelsepilepsyMRItraumatic brain injury

Identifiers

PMID32848013
PMCPMC7572686
OpenAlexW3080718454

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.