ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Cortical Control of Subthalamic Neuronal Activity through the Hyperdirect and Indirect Pathways in Monkeys.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 43 citations in OpenAlex.
- Dopamine amplifies subthalamic long-latency responses to cortical stimulation in patients with Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Cortical Contributions to Attentional Orienting and Response Cancellation in Action Stopping.Psychophysiology · 2026Article
- Distinct contributions of two subpopulations of subthalamic neurons to levodopa-induced dyskinesia.Science advances · 2026Article
- Dynamic modeling in neurocognitive frameworks of childhood ADHD: a review of inhibitory control and reward systems.Translational psychiatry · 2026Review
- Deep brain stimulation reduces subthalamic nucleus pathological dynamics and rescues gait deficits associated with dopamine loss.bioRxiv : the preprint server for biology · 2026Article
- MRI-Guided Focused Ultrasound in Parkinson's Disease and Essential Tremor: Incisionless but Invasive. A Narrative Review.Journal of movement disorders · 2025Article
- Spike Timing-Dependent Plasticity and Random Inputs Shape Interspike Interval Regularity of Model STN Neurons.Biomedicines · 2025Article
- Does Dysregulation Of The Indirect Pathway Contribute To The Pathophysiology Of Catatonia Through Neurotransmitter Imbalance?Clinical neuropsychiatry · 2025Article
- Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson's disease.Nature communications · 2025Article
- Pallidal prototypic neuron and astrocyte activities regulate flexible reward-seeking behaviors.bioRxiv : the preprint server for biology · 2025Article
- Ameliorating motor performance and quality of life in Parkinson's disease: a comparison of deep brain stimulation and focused ultrasound surgery.Frontiers in neurology · 2025Review
- Neuroplasticity in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Subthalamic nucleus-language network connectivity predicts dopaminergic modulation of speech function in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Subthalamic Activity for Motor Execution and Cancelation in Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Contribution of the subthalamic nucleus to motor, cognitive and limbic processes: an electrophysiological and stimulation study in monkeys.Frontiers in neuroscience · 2024Article
- The indirect pathway of the basal ganglia promotes transient punishment but not motor suppression.Neuron · 2023Article
- Synaptic network structure shapes cortically evoked spatio-temporal responses of STN and GPe neurons in a computational model.Frontiers in neuroinformatics · 2023Article
- Article
- Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia.Nature communications · 2022Article
- "The Heart Asks Pleasure First"-Conceptualizing Psychiatric Diseases asBrain sciences · 2022Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The subthalamic nucleus (STN) plays a key role in the control of voluntary movements and basal ganglia disorders, such as Parkinson's disease and hemiballismus. The STN receives glutamatergic inputs directly from the cerebral cortex via the cortico-STN hyperdirect pathway and GABAergic inputs from the external segment of the globus pallidus (GPe) via the cortico-striato-GPe-STN indirect pathway. The STN then drives the internal segment of the globus pallidus, which is the output nucleus of the basal ganglia. Thus, clarifying how STN neuronal activity is controlled by the two inputs is crucial. Cortical stimulation evokes early excitation and late excitation in STN neurons, intervened by a short gap. Here, to examine the origin of each component of this biphasic response, we recorded neuronal activity in the STN, combined with electrical stimulation of the motor cortices and local drug application in two male monkeys (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.