Twinkle-associated familial parkinsonism with Lewy pathology: Cause or predisposition?

David P Breen, David G Munoz, Anthony E Lang

Open access · bronzeAbstract readCase Reports

In one paragraph

Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it

0cells of the map it votes in

7citing papers in PubMed

0.6field-weighted citation impact, top 32% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

Rethinking Mitochondrial Parkinson's Disease in the α-Synuclein Seed Amplification Assays Era.Movement disorders : official journal of the Movement Disorder Society · 2026
Article
Mitochondrial Dysfunction in Genetic and Non-Genetic Parkinson's Disease.International journal of molecular sciences · 2025
Review
Mitochondrial Parkinsonism: A Practical Guide to Genes and Clinical Diagnosis.Movement disorders clinical practice · 2024
Review
TWNK in Parkinson's Disease: A Movement Disorder and Mitochondrial Disease Center Perspective Study.Movement disorders : official journal of the Movement Disorder Society · 2022
Article
Tau Pathology Associated With Parkinsonism and Mutation of Mitochondrial DNA Helicase GeneNeurology. Genetics · 2021
Article
Is there a special relationship between complex I activity and nigral neuronal loss in Parkinson's disease? A critical reappraisal.Brain research · 2021
Review
Selective Neuron Vulnerability in Common and Rare Diseases-Mitochondria in the Focus.Frontiers in molecular biosciences · 2021
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

David P BreenFrom the Centre for Clinical Brain Sciences (D.P.B.), University of Edinburgh; Anne Rowling Regenerative Neurology Clinic (D.P.B.), University of Edinburgh; Usher Institute of Population Health Sciences and Informatics (D.P.B.), University of Edinburgh, Scotland; Department of Laboratory Medicine (D.G.M.), St Michael's Hospital, Toronto, Canada; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (A.E.L.), Toronto Western Hospital; Department of Medicine (A.E.L.), University of Toronto; and Krembil Research Institute (A.E.L.), Toronto Western Hospital, Ontario, Canada.

David G MunozFrom the Centre for Clinical Brain Sciences (D.P.B.), University of Edinburgh; Anne Rowling Regenerative Neurology Clinic (D.P.B.), University of Edinburgh; Usher Institute of Population Health Sciences and Informatics (D.P.B.), University of Edinburgh, Scotland; Department of Laboratory Medicine (D.G.M.), St Michael's Hospital, Toronto, Canada; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (A.E.L.), Toronto Western Hospital; Department of Medicine (A.E.L.), University of Toronto; and Krembil Research Institute (A.E.L.), Toronto Western Hospital, Ontario, Canada.

Anthony E LangFrom the Centre for Clinical Brain Sciences (D.P.B.), University of Edinburgh; Anne Rowling Regenerative Neurology Clinic (D.P.B.), University of Edinburgh; Usher Institute of Population Health Sciences and Informatics (D.P.B.), University of Edinburgh, Scotland; Department of Laboratory Medicine (D.G.M.), St Michael's Hospital, Toronto, Canada; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (A.E.L.), Toronto Western Hospital; Department of Medicine (A.E.L.), University of Toronto; and Krembil Research Institute (A.E.L.), Toronto Western Hospital, Ontario, Canada. Anthony.Lang@uhnresearch.ca.ORCID 0000-0003-1229-3667

St. Michael's Hospital · CA

Funding

Wellcome TrustWellcome Trust 214571/Z/18/Z

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA HelicasesHumansLewy Body DiseaseMaleMiddle AgedMitochondrial ProteinsMutationParkinson DiseaseDNA HelicasesMitochondrial ProteinsTWNK protein, human

Identifiers

PMID32847958

DOI10.1212/WNL.0000000000010674

PMCPMC7682839

OpenAlexW3080525334

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.