Evidence map›Paper›PMID 32847936›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2020

Characteristics and Outcomes for Secondary Breast Cancer in Childhood, Adolescent, and Young Adult Cancer Survivors Treated with Radiation.

Candice A M Sauder, Qian Li, Alisha Othieno, Daisy Cruz, Mili Arora, Richard J Bold, Fredrick J Meyers, Theresa H M Keegan

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Candice A M SauderDivision of Surgical Oncology, Department of Surgery, University of California, Davis Medical Center, Sacramento, California. camsauder@ucdavis.edu.
Qian LiCenter for Oncology and Hematology Outcomes Research and Training (COHORT) and Division of Hematology and Oncology, University of California, Davis School of Medicine, Sacramento, California.
Alisha OthienoDivision of Surgical Oncology, Department of Surgery, University of California, Davis Medical Center, Sacramento, California.ORCID 0000-0002-3481-8359
Daisy CruzDivision of Surgical Oncology, Department of Surgery, University of California, Davis Medical Center, Sacramento, California.
Mili AroraComprehensive Cancer Center, University of California, Davis Medical Center, Sacramento, California.
Richard J BoldDivision of Surgical Oncology, Department of Surgery, University of California, Davis Medical Center, Sacramento, California.
Fredrick J MeyersComprehensive Cancer Center, University of California, Davis Medical Center, Sacramento, California.
Theresa H M KeeganCenter for Oncology and Hematology Outcomes Research and Training (COHORT) and Division of Hematology and Oncology, University of California, Davis School of Medicine, Sacramento, California.
University of California Davis Medical Center · USUniversity of California, Davis · US

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura Marcu · 2002 to 2026
$84.9M
NCCDPHP CDC HHS NU58DP006344NCI NIH HHS HHSN261201800009CNCI NIH HHS HHSN261201800009INCI NIH HHS HHSN261201800015CNCI NIH HHS HHSN261201800015INCI NIH HHS HHSN261201800032CNCI NIH HHS HHSN261201800032INCI NIH HHS P30 CA093373
6 · The paper itself

Abstract

backgroundRadiotherapy is used to treat many adolescent and young adult (AYA) and childhood cancer patients and is a risk factor for secondary breast cancer. While premenopausal breast cancer is inherently more aggressive, no studies to date have evaluated the characteristics and breast cancer-specific survival (BCSS) of premenopausal secondary breast cancer after radiotherapy in AYA and childhood cancer survivors.

methodsFemale patients ages 12 to 50 diagnosed with primary breast cancer from 1988 to 2014 (

resultsThe secondary breast cancer cohort was more likely to be Hispanic or Black, be 35 to 45 years of age, have earlier stage tumors, be higher grade, have no lymph node involvement, and be hormone receptor negative. All women showed worse BCSS for large tumor size, lymph node involvement, and hormone receptor-negative status. BCSS was worse for women with secondary breast cancer both overall (hazard ratio, 1.98; 95% confidence interval, 1.77-2.23) and in all subgroups considered. Associations were most pronounced in Hispanics, Asian/Pacific Islanders, and younger women, as well as those with earlier stage, lymph node-negative, and hormone receptor-positive disease.

conclusionsBCSS is significantly decreased among all survivors of childhood and AYA cancer treated with radiotherapy that develop a secondary breast cancer, including women with good prognostic features. IMPACT: Therefore, we may need to consider alternative and even more aggressive treatment in what were considered low-risk populations previously.

Indexed as

AdolescentAdultBreast NeoplasmsCancer SurvivorsChildHumansMiddle AgedTreatment OutcomeYoung Adult

Identifiers

PMID32847936
PMCPMC9377811
OpenAlexW3080477956

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.