Evidence map›Paper›PMID 32847862›Full record

ArticleJournal of virology2020

Human Monoclonal Antibody Derived from Transchromosomic Cattle Neutralizes Multiple H1 Clades of Influenza A Virus by Recognizing a Novel Conformational Epitope in the Hemagglutinin Head Domain.

Rongyuan Gao, Chithra C Sreenivasan, Zizhang Sheng, Ben M Hause, Bin Zhou, David E Wentworth, Travis Clement, Dana Rausch, Colin Brunick, Jane Christopher-Hennings and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Protective and pathogenic role of humoral responses in COVID-19.Journal of microbiology (Seoul, Korea) · 2022
    Review
  6. The contribution of bovines to human health against viral infections.Environmental science and pollution research international · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Rongyuan GaoDepartment of Biology and Microbiology, South Dakota State University, Brookings, South Dakota, USA.
Chithra C SreenivasanDepartment of Biology and Microbiology, South Dakota State University, Brookings, South Dakota, USA.
Zizhang ShengZuckerman Mind Brain Behavior Institute, Columbia University, New York, New York, USA.
Ben M HauseDepartment of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, South Dakota, USA.
Bin ZhouInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
David E WentworthInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Travis ClementDepartment of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, South Dakota, USA.
Dana RauschDepartment of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, South Dakota, USA.
Colin BrunickDivision of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota, USA.
Jane Christopher-HenningsDepartment of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, South Dakota, USA.
Hua WuSAB Biotherapeutics, Sioux Falls, South Dakota, USA.
Christoph L BauschSAB Biotherapeutics, Sioux Falls, South Dakota, USA.
Eddie J SullivanSAB Biotherapeutics, Sioux Falls, South Dakota, USA.
Adam D HoppeDepartment of Chemistry and Biochemistry, South Dakota State University, Brookings, South Dakota, USA.
Victor C HuberBioSNTR, Brookings, South Dakota, USA.
Dan WangDepartment of Biology and Microbiology, South Dakota State University, Brookings, South Dakota, USA dan.wang@sdstate.edu feng.li@sdstate.edu.ORCID 0000-0002-7263-8420
Feng LiDepartment of Biology and Microbiology, South Dakota State University, Brookings, South Dakota, USA dan.wang@sdstate.edu feng.li@sdstate.edu.ORCID 0000-0002-8904-2893
South Dakota State University · USSab Biotherapeutics (United States) · USCenters for Disease Control and Prevention · USUniversity of South Dakota · USColumbia University · US

Funding

Wichozani-A Healthy Lifestyle for Rural American Indian Youth through Cultural and Physical Activities: A Community-Based Participatory Research StudyP20GM103443 · NIGMS · UNIVERSITY OF SOUTH DAKOTA · PI Ryan Michael Johnson · 2012 to 2026
$58.1M
NIGMS NIH HHS P20 GM103443
6 · The paper itself

Abstract

Influenza remains a global health risk and challenge. Currently, neuraminidase (NA) inhibitors are extensively used to treat influenza, but their efficacy is compromised by the emergence of drug-resistant variants. Neutralizing antibodies targeting influenza A virus surface glycoproteins are critical components of influenza therapeutic agents and may provide alternative strategies to the existing countermeasures. However, the major hurdle for the extensive application of antibody therapies lies in the difficulty of generating nonimmunogenic antibodies in large quantities rapidly. Here, we report that one human monoclonal antibody (MAb), 53C10, isolated from transchromosomic (Tc) cattle exhibits potent neutralization and hemagglutination inhibition titers against different clades of H1N1 subtype influenza A viruses.

Indexed as

AnimalsAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralCattleCell LineEpitopesHemagglutinin Glycoproteins, Influenza VirusHumansImmune EvasionInfluenza A virusInfluenza A Virus, H1N1 SubtypeModels, MolecularMutationNeutralization TestsOrthomyxoviridae InfectionsAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralEpitopesHemagglutinin Glycoproteins, Influenza Virusepitopeinfluenzamonoclonal antibodiesneutralizing antibodies

Identifiers

PMID32847862
PMCPMC7592206
OpenAlexW3080288698

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.