ArticleGenetics2020
Background Selection Does Not Mimic the Patterns of Genetic Diversity Produced by Selective Sweeps.
Article in Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- A population genomic resource for Drosophila pseudoobscura.G3 (Bethesda, Md.) · 2026Article
- Genetic Footprints of Seasonal Fluctuating Selection: A Comparison With Established Selection Forms.Genome biology and evolution · 2026Article
- Identifying Adaptive Footprints in the Presence of Demographic Uncertainty.Genome biology and evolution · 2026Article
- ThebioRxiv : the preprint server for biology · 2026Article
- Recombination Rate and Recurrent Linked Selection Shape Correlated Genomic Landscapes Across a Continuum of Divergence in Swallows.Molecular ecology · 2025Article
- Accessible, Realistic Genome Simulation with Selection Using stdpopsim.Molecular biology and evolution · 2025Article
- Accessible, realistic genome simulation with selection using stdpopsim.bioRxiv : the preprint server for biology · 2025Article
- Evolution of Functional Genomic Diversity During a Bottleneck.Genome biology and evolution · 2025Article
- Efficient Detection and Characterization of Targets of Natural Selection Using Transfer Learning.Molecular biology and evolution · 2025Article
- Efficient detection and characterization of targets of natural selection using transfer learning.bioRxiv : the preprint server for biology · 2025Article
- Population size rescaling significantly biases outcomes of forward-in-time population genetic simulations.Genetics · 2025Article
- Digital Image Processing to Detect Adaptive Evolution.Molecular biology and evolution · 2024Article
- Evolution of the Correlated Genomic Variation Landscape Across a Divergence Continuum in the Genus Castanopsis.Molecular biology and evolution · 2024Article
- Population size rescaling significantly biases outcomes of forward-in-time population genetic simulations.bioRxiv : the preprint server for biology · 2024Article
- Linked Selection and Gene Density Shape Genome-Wide Patterns of Diversification in Peatmosses.Evolutionary applications · 2024Article
- Enrichment of hard sweeps on the X chromosome compared to autosomes in six Drosophila species.Genetics · 2024Article
- Shared evolutionary processes shape landscapes of genomic variation in the great apes.Genetics · 2024Article
- Genomic Architecture Predicts Tree Topology, Population Structuring, and Demographic History in Amazonian Birds.Genome biology and evolution · 2024Article
- selscan 2.0: scanning for sweeps in unphased data.Bioinformatics (Oxford, England) · 2024Article
- Enrichment of hard sweeps on the X chromosome compared to autosomes in six Drosophila species.bioRxiv : the preprint server for biology · 2023Article
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Abstract
It is increasingly evident that natural selection plays a prominent role in shaping patterns of diversity across the genome. The most commonly studied modes of natural selection are positive selection and negative selection, which refer to directional selection for and against derived mutations, respectively. Positive selection can result in hitchhiking events, in which a beneficial allele rapidly replaces all others in the population, creating a valley of diversity around the selected site along with characteristic skews in allele frequencies and linkage disequilibrium among linked neutral polymorphisms. Similarly, negative selection reduces variation not only at selected sites but also at linked sites, a phenomenon called background selection (BGS). Thus, discriminating between these two forces may be difficult, and one might expect efforts to detect hitchhiking to produce an excess of false positives in regions affected by BGS. Here, we examine the similarity between BGS and hitchhiking models via simulation. First, we show that BGS may somewhat resemble hitchhiking in simplistic scenarios in which a region constrained by negative selection is flanked by large stretches of unconstrained sites, echoing previous results. However, this scenario does not mirror the actual spatial arrangement of selected sites across the genome. By performing forward simulations under more realistic scenarios of BGS, modeling the locations of protein-coding and conserved noncoding DNA in real genomes, we show that the spatial patterns of variation produced by BGS rarely mimic those of hitchhiking events. Indeed, BGS is not substantially more likely than neutrality to produce false signatures of hitchhiking. This holds for simulations modeled after both humans and
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