Evidence map›Paper›PMID 32847766›Full record

ArticleSeizure2020

Focal cortical dysplasia imaging discrepancies between MRI and FDG-PET: Unique association with temporal lobe location.

Hajime Yokota, Hiroyuki Uetani, Hiroyuki Tatekawa, Akifumi Hagiwara, Emiko Morimoto, Michael Linetsky, Bryan Yoo, Benjamin M Ellingson, Noriko Salamon

Open access · greenAbstract read
In one paragraph

Article in Seizure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Neuropsychiatric disease and treatment · 2024
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Hajime YokotaDepartment of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States; Department of Diagnostic Radiology and Radiation Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Hiroyuki UetaniDepartment of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States; Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan. Electronic address: hiromaelen5@gmail.com.
Hiroyuki TatekawaDepartment of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States; Department of Diagnostic and Interventional Radiology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Akifumi HagiwaraDepartment of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States; Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan.
Emiko MorimotoDepartment of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States; Department of Diagnostic and Interventional Radiology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Michael LinetskyDepartment of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Bryan YooDepartment of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Benjamin M EllingsonDepartment of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States; UCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision and Imaging Biomarkers, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, United States.
Noriko SalamonDepartment of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
University of California, Los Angeles · USChiba University · JP

Funding

UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI David A. Nathanson · 2017 to 2026
$25.2M
Metabolic MRI for quantifying aerobic glycolysis and immune function in gliomasR21CA223757 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ELLINGSON, BENJAMIN M. · 2018 to 2019
$366k
NCI NIH HHS P50 CA211015NCI NIH HHS R21 CA223757
6 · The paper itself

Abstract

purposeAlthough magnetic resonance imaging (MRI) and

methodsSixty-two patients (mean age, 18.9 years) with a FCD type I or II were retrospectively selected. These patients were visually categorized into two groups: 1) extent of PET abnormality larger than MRI abnormality and 2) vice versa or equivalent. Predictive factors of these two groups were analyzed by multivariate logistic regression. The extent of hypometabolic transient zone surrounding FCDs and their mean standardized uptake values were measured and compared by the Mann-Whitney U-test.

resultsFCDs were detected on MRI and PET in 46 and 55 patients, respectively, whereas no abnormality was detected in 4 patients. The PET hypometabolic areas were larger than the MRI abnormal areas in 26 patients (88 % in the temporal lobe), whereas the PET hypometabolic areas were equivalent or smaller than the MRI abnormal areas in 32 patients (69 % in the frontal lobe). The temporal lobe location was an independent predictor for differentiating the two groups (OR = 35.2, 95 % CI = 6.81-168.0, P < .001). The temporal lobe lesions had significantly wider transient zones and lower standardized uptake values than those in the other lobes (P < .001, both).

conclusionThe discrepancies between MRI and FDG-PET findings of FCD were associated with temporal lobe location.

Indexed as

Epilepsy, Temporal LobeMalformations of Cortical DevelopmentAdolescentFluorodeoxyglucose F18HumansMagnetic Resonance ImagingPositron-Emission TomographyRetrospective StudiesTemporal LobeFluorodeoxyglucose F18FDG PETFocal cortical dysplasiaHypometabolismMRITemporal lobe

Identifiers

PMID32847766
PMCPMC8216482
OpenAlexW3049432187

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.