Evidence map›Paper›PMID 32847738›Full record

SynthesisBrazilian journal of otorhinolaryngology

Efficacy of chemiluminescence in the diagnosis and screening of oral cancer and precancer: a systematic review and meta-analysis.

Do Hyun Kim, Jaeyoon Lee, Min Hyeong Lee, Sung Won Kim, Se Hwan Hwang

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Do Hyun KimThe Catholic University of Korea, College of Medicine, Seoul St. Mary's Hospital, Department of Otolaryngology-Head and Neck Surgery, Seoul, Korea.
Jaeyoon LeeThe Catholic University of Korea, College of Medicine, Seoul St. Mary's Hospital, Department of Otolaryngology-Head and Neck Surgery, Seoul, Korea.
Min Hyeong LeeThe Catholic University of Korea, College of Medicine, Seoul St. Mary's Hospital, Department of Otolaryngology-Head and Neck Surgery, Seoul, Korea.
Sung Won KimThe Catholic University of Korea, College of Medicine, Seoul St. Mary's Hospital, Department of Otolaryngology-Head and Neck Surgery, Seoul, Korea.
Se Hwan HwangThe Catholic University of Korea, College of Medicine, Bucheon St. Mary's Hospital, Department of Otolaryngology-Head and Neck Surgery, Seoul, Korea. Electronic address: yellobird@catholic.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEarly detection of potentially malignant oral cavity disorders is critical for a good prognosis, and it is unclear whether the use of chemiluminescence as an adjunctive diagnostic screening method improves diagnostic accuracy.

objectiveThis systematic review and meta-analysis was performed to assess the accuracy of chemiluminescence for diagnosis of oral cancer and precancerous lesions.

methodsSixteen prospective and retrospective studies from PubMed, Cochrane database, SCOPUS, Web of Science, Embase, and Google Scholar were reviewed. Oral mucosal disorder, as detected by chemiluminescence, was compared with oral mucosal disorder detected by toluidine blue or visual examination. True-positive, true-negative, false-positive, and false-negative rates were extracted for each study. Methodological quality was evaluated using the Quality Assessment of Diagnostic Accuracy Studies tool (ver. 2).

resultsSensitivity, specificity, negative predictive value, and diagnostic odds ratio (DOR) of the use of toluidine blue were 0.832 (95% confidence interval [CI] 0.692-0.917), 0.429 (95% CI 0.217-0.672), 0.747 (95% CI 0.607-0.849), and 4.061 (95% CI 1.528-10.796; I

conclusionAlthough chemiluminescence itself has good sensitivity for diagnostic work-up of oral cancer and precancer, the diagnostic accuracy of chemiluminescence is comparable to or worse than toluidine blue and clinical examination. Diagnostic accuracy was therefore insufficient for reliable use of chemiluminescence alone.

Indexed as

Mouth DiseasesMouth NeoplasmsEarly Detection of CancerHumansLuminescenceProspective StudiesRetrospective StudiesSensitivity and SpecificityTolonium ChlorideTolonium ChlorideChemiluminescenceMouth neoplasmsPrecancerous conditionsTolonium chloride

Identifiers

PMID32847738
PMCPMC9422469

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.