ArticleBreast cancer research : BCR2020
Hormonal determinants of mammographic density and density change.
Article in Breast cancer research : BCR, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Side effects of low-dose tamoxifen: results from a six-armed randomised controlled trial in healthy women.British journal of cancer · 2023Trial
- Evaluating mammographic density polygenic risk score for contralateral breast cancer risk prediction.Scientific reports · 2026Article
- Steroid hormone metabolites and mammographic breast density in premenopausal women.British journal of cancer · 2026Article
- Circulating sex hormones and volumetric breast density: A prospective study in women from the EPIC Florence cohort.International journal of cancer · 2025Article
- Lifecourse Growth and Development Determinants of Mammographic Density in Black Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Dense breast tissue in screened postmenopausal women: Prevalence and determinants.Saudi medical journal · 2024Article
- The risk of endocrine interventions in carriers of a genetic predisposition for breast and gynecologic cancers: recommendations of the German Consortium for Hereditary Breast and Ovarian Cancer.Journal of cancer research and clinical oncology · 2024Review
- PFAS Levels, Early Life Factors, and Mammographic Breast Density in Premenopausal Women.Environmental health perspectives · 2024Article
- Adiposity, Body Composition Measures, and Breast Cancer Risk in Korean Premenopausal Women.JAMA network open · 2024Article
- Assessing the knowledge, attitudes and barriers regarding health promotion of breast cancer among community pharmacists.Future science OA · 2022Article
- Hormone and receptor activator of NF-κB (RANK) pathway gene expression in plasma and mammographic breast density in postmenopausal women.Breast cancer research : BCR · 2022Article
- Evaluation of the association of endometriosis and mammographic breast density, a cross-sectional study.BMC women's health · 2022Article
- The epidemiologic factors associated with breast density: A review.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2022Review
- The Other Side of the Coin: May Androgens Have a Role in Breast Cancer Risk?International journal of molecular sciences · 2021Review
- Fatty liver disease and changes in dense breasts in pre- and postmenopausal women: the Kangbuk Samsung Health Study.Breast cancer research and treatment · 2021Article
- Pharmacists' knowledge, attitudes, beliefs, and barriers toward breast cancer health promotion: a cross-sectional study in the Palestinian territories.BMC health services research · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMammographic density (MD) is a strong risk factor for breast cancer. We examined how endogenous plasma hormones are associated with average MD area (cm
methodsThis study within the prospective KARMA cohort included analyses of plasma hormones of 1040 women. Hormones from the progestogen (n = 3), androgen (n = 7), oestrogen (n = 2) and corticoid (n = 5) pathways were analysed by ultra-performance supercritical fluid chromatography-tandem mass spectrometry (UPSFC-MS/MS), as well as peptide hormones and proteins (n = 2). MD was measured as a dense area using the STRATUS method (mean over the left and right breasts) and mean annual MD change over time.
resultsGreater baseline mean MD was associated with overall higher concentrations of progesterone (average + 1.29 cm
conclusionsOur results suggest that, whereas hormones from the progestogen, oestrogen and corticoid pathways drive baseline MD, MD change over time is mainly driven by androgens. This study emphasises the complexity of risk factors for breast cancer and their mechanisms of action.
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