ArticleBMC pregnancy and childbirth2020
Relationship between anti-thyroid peroxidase antibody positivity and pregnancy-related and fetal outcomes in Euthyroid women: a single-center cohort study.
Article in BMC pregnancy and childbirth, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02966405 (The Establish of Trimester-specific Reference Ranges for Thyroid Tests in Pregnant Women and the Influence of Thyroid Disorders on Pregnancy and Its Outcomes.), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Establish of Trimester-specific Reference Ranges for Thyroid Tests in Pregnant Women and the Influence of Thyroid Disorders on Pregnancy and Its Outcomes.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Association of thyroid disorders with gestational diabetes mellitus: a meta-analysis.Endocrine · 2021Pooled it
- Association of longitudinal thyroid function parameters with preterm birth: a retrospective cohort study in Jinan, China.BMC pregnancy and childbirth · 2026Article
- Active Antibiotic Treatment Improves ART Outcomes in TPOAb-Positive Chronic Endometritis Patients: A Retrospective Study.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Association of maternal thyroid peroxidase antibody exposure with children's emotional and behavioral problems.European thyroid journal · 2025Article
- Higher prevalence of gestational diabetes in euthyroid women with thyroid autoimmunity who were expecting a female fetus.European thyroid journal · 2025Article
- A retrospective analysis on maternal and neonatal outcomes in pSS/AITD pregnancies.Scientific reports · 2025Article
- Impact of thyroid autoantibodies on pregnancy: A prospective cohort study.Bioinformation · 2025Article
- Article
- A study of autoimmune thyroid disease in pregnant women and its effect on fetal and maternal outcome.Journal of family medicine and primary care · 2024Article
- Iodine nutritional status and its associations with thyroid function of pregnant women and neonatal TSH.Frontiers in endocrinology · 2024Article
- Influence of thyroid autoimmunity at various clinical stages of hypothyroidism on the risk of miscarriage before 20 weeks of gestation.Hormones (Athens, Greece) · 2023Article
- Gestation-suppressed serum TSH levels during early pregnancy are not associated with altered maternal and neonatal outcomes.European thyroid journal · 2023Article
- Thyroid Peroxidase Antibodies in Infertile Women with Polycystic Ovary Syndrome.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Maternal preconception thyroid autoimmunity is associated with neonatal birth weight conceived by PCOS women undergoing their first in vitro fertilization/intracytoplasmic sperm injection.Journal of ovarian research · 2023Article
- The association between hypothyroidism and perinatal outcomes in patients with polycystic ovary syndrome.Archives of gynecology and obstetrics · 2023Article
- The Thyroid Hormone Axis and Female Reproduction.International journal of molecular sciences · 2023Review
- First trimester sCD40L levels associated with adverse neonatal outcomes in euthyroid pregnant women with positive TPOAb.Frontiers in endocrinology · 2023Article
- Maternal thyroid peroxidase antibody positivity and its association with incidence of low birth weight in infants.Frontiers in endocrinology · 2023Article
- Maternal isolated hypothyroxinemia in the first trimester is not associated with adverse pregnancy outcomes, except for macrosomia: a prospective cohort study in China.Frontiers in endocrinology · 2023Article
- A Bayesian model to estimate the cutoff value of TSH for management of preterm birth.PloS one · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThyroid autoimmunity (TAI) and subclinical hypothyroidism (SCH) have been associated with poor pregnancy and fetal outcomes. However, whether euthyroid women with anti-thyroid peroxidase antibody (TPOAb) positivity have a higher risk of poor pregnancy and fetal outcomes is debatable. Therefore, this study aimed to investigate the association between TPOAb positivity and pregnancy-related and fetal outcomes in euthyroid women.
methodsIn total, 938 pregnant women participated in this prospective cohort study. The euthyroid group included 837 pregnant women and the TPOAb-positive group included 101 euthyroid pregnant women. Serum TPOAb, thyroglobulin antibody (TGAb), thyroid-stimulating hormone (TSH), and free thyroxine (FT4) levels were assessed. Pregnancy and fetal outcomes included gestational diabetes mellitus, spontaneous abortion, premature rupture of membranes, hypertensive disorders of pregnancy, preterm birth, fetal distress, low birth weight, fetal macrosomia, and small for gestational age infant.
resultsLogistic regression analysis showed TPOAb positivity was not associated with an increased risk of poor pregnancy or fetal outcomes in euthyroid women. However, TPOAb-positive euthyroid women pregnant with a female fetus were independently associated with preterm births (OR: 4.511, 95% CI: 1.075-18.926) after adjustment for potential confounding factors.
conclusionsTPOAb positivity was not found to be associated with poor pregnancy-related or fetal outcomes in euthyroid women. However, in euthyroid women with a female fetus, TPOAb positivity was strongly associated with preterm births. The risk of preterm birth in the euthyroid women with TPOAb positivity should be emphasized in clinical practice.
trial registrationClinicalTrials.gov Identifier: NCT02966405 . Registered on October 24th 2016 - Retrospectively registered.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.