Evidence map›Paper›PMID 32847506›Full record

ArticleBMC cardiovascular disorders2020

Anti-modified citrullinated vimentin antibody: a novel biomarker associated with cardiac systolic dysfunction in patients with rheumatoid arthritis.

Somayye Norouzi, Ali Javinani, Arya Aminorroaya, Maryam Masoumi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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  7. NETosis as a Pathogenic Factor for Heart Failure.Oxidative medicine and cellular longevity · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Somayye NorouziDepartment of Internal Medicine, Qom University of Medical Sciences, Qom, Iran.
Ali JavinaniRheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Arya AminorroayaTehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
Maryam MasoumiClinical Research Development Center, Shahid Beheshti Hospital, Qom University of Medical Sciences, Azadegan Sq., Shahid Beheshti Blvd, Qom, Iran. mmasoomi@muq.ac.ir.ORCID 0000-0003-2635-2656
Tehran University of Medical Sciences · IRQom University of Medical Science and Health Services · IRShahid Beheshti University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudies have demonstrated that seropositive patients with rheumatoid arthritis (RA) are susceptible to cardiovascular diseases (CVDs). In this study, we aimed to determine the association of autoantibodies with the echocardiographic parameters of systolic and diastolic dysfunction in such patients.

methodsIn this cross-sectional study, we evaluated patients with RA who were referred to our clinic from October 2017 to August 2018. After the exclusion of patients with concomitant CVD, all patients underwent transthoracic echocardiography and measurement of plasma autoantibodies. Moreover, possible confounders-including medications, CVD risk factors, Framingham risk score, disease activity score-28, duration of disease, simple disease activity index, and functional status-were assessed.

resultsWe studied 135 patients with RA (mean age = 52.3 years; 111 (82.2%) females). We had missing data rates of up to 8.9% for some characteristics. E velocity was inversely correlated with rheumatoid factor (P = 0.009). Furthermore, the plasma levels of anti-citrullinated protein and anti-modified citrullinated vimentin (anti-MCV) antibodies were negatively correlated with left ventricular ejection fraction (LVEF) (P = 0.019 and P<0.001, respectively). After an adjustment for possible confounders, the linear regression model demonstrated that the anti-MCV level and the patient's age are significant predictors of LVEF. The receiver operating characteristic curve showed that anti-MCV antibody titer≥547.5 (IU/mL) signifies reduced LVEF (<50%) with a sensitivity of 85.7% and specificity of 93% (C-statistic = 0.843).

conclusionsOur findings showed a significant inverse correlation between anti-MCV antibody titer and LVEF. These results indicate that the application of anti-MCV is promising for the screening and early detection of cardiac systolic dysfunction. Future prospective studies will determine its role.

Indexed as

Stroke VolumeVentricular Function, LeftAdultAnti-Citrullinated Protein AntibodiesArthritis, RheumatoidBiomarkersCitrullinationCross-Sectional StudiesFemaleHumansMaleMiddle AgedPredictive Value of TestsSystoleVentricular Dysfunction, LeftVimentinAnti-Citrullinated Protein AntibodiesBiomarkersVimentinAnti-citrullinated protein antibodiesAnti-MCVAnti-modified citrullinated vimentinArthritis, rheumatoidAutoantibodiesEchocardiographyEjection fractionRheumatoid factor

Identifiers

PMID32847506
PMCPMC7448352
OpenAlexW3080630526

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.