ArticleThe EMBO journal1988
The glutathione transferase activity and tissue distribution of a cloned Mr28K protective antigen of Schistosoma mansoni.
Article in The EMBO journal, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 176 citations in OpenAlex.
- Innate Immune Response to Helminth Infections.Advances in experimental medicine and biology · 2025Review
- A comprehensive and critical overview of schistosomiasis vaccine candidates.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Review
- Of monkeys and men: immunomic profiling of sera from humans and non-human primates resistant to schistosomiasis reveals novel potential vaccine candidates.Frontiers in immunology · 2015Article
- Eliminating Schistosomes through Vaccination: What are the Best Immune Weapons?Frontiers in immunology · 2015Review
- Cytokine responses to the anti-schistosome vaccine candidate antigen glutathione-S-transferase vary with host age and are boosted by praziquantel treatment.PLoS neglected tropical diseases · 2014Article
- Induction of protective immunity against Schistosoma mansoni via DNA priming and boosting with the large subunit of calpain (Sm-p80): adjuvant effects of granulocyte-macrophage colony-stimulating factor and interleukin-4.Infection and immunity · 2003Article
- Ultrastructural localization of 28 kDa glutathione S-transferase in adult Clonorchis sinensis.The Korean journal of parasitology · 2002Article
- Tetanus toxin fragment C expressed in live Salmonella vaccines enhances antibody responses to its fusion partner Schistosoma haematobium glutathione S-transferase.Infection and immunity · 2000Article
- Single-dose mucosal immunization with biodegradable microparticles containing a Schistosoma mansoni antigen.Infection and immunity · 1999Article
- Infection with Salmonella typhimurium modulates the immune response to Schistosoma mansoni glutathione-S-transferase.Infection and immunity · 1997Article
- Structural and functional analysis of a glutathione S-transferase from Ascaris suum.The Biochemical journal · 1997Article
- The A-domain of beta 2 integrin CR3 (CD11b/CD18) is a receptor for the hookworm-derived neutrophil adhesion inhibitor NIF.The Journal of cell biology · 1994Article
- Construction, expression, and immunogenicity of the Schistosoma mansoni P28 glutathione S-transferase as a genetic fusion to tetanus toxin fragment C in a live Aro attenuated vaccine strain of Salmonella.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Protective effect of rSm28GST-specific T cells in schistosomiasis: role of gamma interferon.Infection and immunity · 1994Article
- Resistance induced by drug abbreviated Schistosoma mansoni infections: treatment with the drug Ro11-3128 leads to enhanced antigen presentation.Immunology · 1994Article
- An evolutionary perspective on glutathione transferases inferred from class-theta glutathione transferase cDNA sequences.The Biochemical journal · 1992Article
- Activated eosinophils in adult coeliac disease: evidence for a local release of major basic protein.Gut · 1992Article
- Identification of the major soluble cuticular glycoprotein of lymphatic filarial nematode parasites (gp29) as a secretory homolog of glutathione peroxidase.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- cDNA cloning and functional expression of the Schistosoma mansoni protective antigen triose-phosphate isomerase.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Structure of human glutathione S-transferase class Mu genes.The Biochemical journal · 1991Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A protective Mr28K antigen of Schistosoma mansoni, expressed from its cDNA, has been purified in a single step and shown to possess glutathione (GSH) transferase activity as predicted from sequence homologies with two mammalian GSH transferase multigene families. It is notable for its high 1-chloro-2,4-dinitrobenzene GSH transferase and linoleic acid hydroperoxide GSH peroxidase activities. The major GSH transferase of S. mansoni has been purified and its subunit is identical to this Mr28K antigen by criteria of Mr, immunochemistry, substrate specificity and peptide sequence analysis. In the parasite, the antigen is present in the tegument, protonephridial cells and subtegumental parenchymal cells. No significant immunological cross-reactivity between the S.mansoni and mammalian (human and rat) GSH transferases was observed.
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