Evidence map›Paper›PMID 32847397›Full record

Trial reportAmerican journal of physiology. Regulatory, integrative and comparative physiology2020

Eight weeks of device-guided slow breathing decreases sympathetic nervous reactivity to stress in posttraumatic stress disorder.

Ida T Fonkoue, Yingtian Hu, Toure Jones, Monica Vemulapalli, Justin D Sprick, Barbara Rothbaum, Jeanie Park

2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in American journal of physiology. Regulatory, integrative and comparative physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01627301 narecruitingnot on this map

Mechanisms of Sympathetic Overactivity in Post-traumatic Stress Disorder

TypeinterventionalSponsorEmory UniversityRan2012 to 2027Enrolled120ConditionsPost-traumatic Stress Disorder, PrehypertensionArmsDevice-Guided Breathing (DGB), Sham DGB, Transcutaneous Vagal Nerve Stimulation (tVNS), Sham tVNS
NCT05022550 nacompletednot on this mapstarted 2022, after this paper: background citation

Virtual-reality and Emotion Regulation in Violence-Exposed Youth

TypeinterventionalSponsorUniversity of Wisconsin, MadisonRan2022 to 2025Enrolled74ConditionsEmotional Regulation, Adolescent BehaviorArmsDEEP VR
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. The A52 Breath Method: A Narrative Review of Breathwork for Mental Health and Stress Resilience.Stress and health : journal of the International Society for the Investigation of Stress · 2025
    Review
  8. Article
  9. Article
  10. Decreased COCommunications psychology · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ida T FonkoueRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.ORCID 0000-0003-3282-5739
Yingtian HuDepartment of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, Georgia.
Toure JonesRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Monica VemulapalliRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Justin D SprickRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Barbara RothbaumPsychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia.ORCID 0000-0002-8793-7124
Jeanie ParkRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.ORCID 0000-0002-5799-9172
Emory University · US

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Institutional Career Development CoreKL2TR002381 · NCATS · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Anandi Nayan Sheth · 2017 to 2026
$14.1M
Neuro HPA Project 1U54AG062334 · NIA · EMORY UNIVERSITY · PI Ighovwerha Ofotokun · 2018 to 2026
$12.2M
Neurovascular Regulation During Exercise In Humans With Chronic Kidney DiseaseR01HL135183 · NHLBI · EMORY UNIVERSITY · PI Jeanie Park · 2017 to 2026
$5.4M
Sympatho-inhibition with Mindfulness in Chronic Kidney DiseaseR61AT010457 · NCCIH · EMORY UNIVERSITY · PI PARK, JEANIE · 2019 to 2020
$946k
Mechanisms of Sympathetic Overactivity in Post-traumatic Stress DisorderI01CX001065 · VA · VETERANS HEALTH ADMINISTRATION · PI PARK, JEANIE · 2015 to 2024
–
CSRD VA I01 CX001065HHS | NIH | National Center for Complementary and Alternative Medicine (NCCAM) R61AT010457HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI) R01HL135183HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) T32DK00756NCATS NIH HHS KL2 TR002381NCATS NIH HHS UL1 TR002378NCCIH NIH HHS R61 AT010457NHLBI NIH HHS R01 HL135183NIA NIH HHS U54 AG062334U.S. Department of Veterans Affairs (VA) I01CX001065
6 · The paper itself

Abstract

Posttraumatic stress disorder (PTSD) is characterized by increased risk for developing hypertension and cardiovascular disease. We recently showed that device-guided slow breathing (DGB) acutely lowers blood pressure (BP) and muscle sympathetic activity (MSNA) and improves baroreflex sensitivity (BRS) in PTSD. The aim of this study was to assess the long-term benefits of DGB on autonomic function at rest and during stress. We hypothesized that long-term DGB improves arterial BRS and lowers BP and MSNA in PTSD. Twenty-five veterans with PTSD were studied and randomized to either 8 wk of daily DGB (

Indexed as

RespirationAdultBaroreflexBlood PressureDouble-Blind MethodFemaleHeart RateHemodynamicsHumansMaleRespiratory RateStress Disorders, Post-TraumaticStress, PsychologicalSympathetic Nervous SystemVeteransautonomic functionmental stressPTSDslow breathing

Identifiers

PMID32847397
PMCPMC7642907
OpenAlexW3081430592

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.