Evidence map›Paper›PMID 32847113›Full record

ArticleJournal of clinical medicine2020

Impact of Clinical Response to Neoadjuvant Chemotherapy in the Era of Robot Assisted Radical Cystectomy: Results of a Single-Center Experience.

Umberto Anceschi, Aldo Brassetti, Gabriele Tuderti, Maria Consiglia Ferriero, Manuela Costantini, Alfredo Maria Bove, Fabio Calabrò, Paolo Carlini, Sabrina Vari, Riccardo Mastroianni and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Umberto AnceschiDepartment of Urology, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy.
Aldo BrassettiDepartment of Urology, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy.
Gabriele TudertiDepartment of Urology, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy.
Maria Consiglia FerrieroDepartment of Urology, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy.
Manuela CostantiniDepartment of Urology, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy.
Alfredo Maria BoveDepartment of Urology, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy.
Fabio CalabròDepartment of Oncology, San Camillo-Forlanini Hospital, Rome, Circonvallazione Gianicolense 87, 00152 Rome, Italy.
Paolo CarliniDepartment of Oncology, Regina Elena National Cancer Institute, Rome, Via Elio Chianesi 53, 00144 Rome, Italy.
Sabrina VariDepartment of Oncology, Regina Elena National Cancer Institute, Rome, Via Elio Chianesi 53, 00144 Rome, Italy.
Riccardo MastroianniDepartment of Urology, University of Rome, La Sapienza, Rome, Viale del Policlinico 155, 00161 Rome, Italy.
Michele GallucciDepartment of Urology, University of Rome, La Sapienza, Rome, Viale del Policlinico 155, 00161 Rome, Italy.
Giuseppe SimoneDepartment of Urology, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy.
Policlinico Umberto I · ITCarlo Forlanini Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundResponse to neoadjuvant chemotherapy (NACT) has been proven to be an established prognostic factor after open radical cystectomy (ORC). We evaluated the impact of NACT on survival outcomes of a single-institution robotic radical cystectomy (RARC) series.

methodsFrom January 2012 to June 2020, 79 patients were identified. Baseline, demographic, perioperative, and pathologic data were described. Kaplan-Meier with the log-rank test was used to compare overall survival (OS) differences between complete, partial, and no-NACT responders, respectively. Univariable and multivariable regression analyses were performed to identify predictors of OS.

resultsComplete, partial, and absent response to NACT were recorded in 43 (54.4%), 21 (19%), and 15 (26.6%) patients, respectively. A complete response to NACT displayed a trend toward significant higher OS (

conclusionsComplete response to NACT is associated with increased OS probability, but significant nodal residual disease remains the only independent predictor of OS after RARC.

Indexed as

clinical responselymphadenectomymuscle-invasive bladder cancerneoadjuvant chemotherapyoverall survivalrobotic radical cystectomyurothelial carcinoma

Identifiers

PMID32847113
PMCPMC7564756
OpenAlexW3081234112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.