Evidence map›Paper›PMID 32847103›Full record

ReviewInternational journal of molecular sciences2020

Extracellular Vesicles in the Development of Cancer Therapeutics.

Haoyao Sun, Stephanie Burrola, Jinchang Wu, Wei-Qun Ding

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Systematic review: Association between circulating microRNA expression & stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Pooled it
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  12. Reciprocal communication between FAPs and muscle cells via distinct extracellular vesicle miRNAs in muscle regeneration.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Haoyao SunDepartment of Pathology, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
Stephanie BurrolaDepartment of Pathology, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
Jinchang WuDepartment of Radiation Oncology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215001, China.
Wei-Qun DingDepartment of Pathology, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.ORCID 0000-0001-7358-3700
University of Oklahoma Health Sciences Center · USSuzhou Municipal Hospital · CNXuzhou Medical College · CN

Funding

The initiation of exosome microRNA signaling in pancreatic cancer cellsR03CA235208 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI DING, WEI-QUN · 2019 to 2020
$145k
NCI NIH HHS CA235208-01NCI NIH HHS R03 CA235208
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are small lipid bilayer-delimited nanoparticles released from all types of cells examined thus far. Several groups of EVs, including exosomes, microvesicles, and apoptotic bodies, have been identified according to their size and biogenesis. With extensive investigations on EVs over the last decade, it is now recognized that EVs play a pleiotropic role in various physiological processes as well as pathological conditions through mediating intercellular communication. Most notably, EVs have been shown to be involved in cancer initiation and progression and EV signaling in cancer are viewed as potential therapeutic targets. Furthermore, as membrane nanoparticles, EVs are natural products with some of them, such as tumor exosomes, possessing tumor homing propensity, thus leading to strategies utilizing EVs as drug carriers to effectively deliver cancer therapeutics. In this review, we summarize recent reports on exploring EVs signaling as potential therapeutic targets in cancer as well as on developing EVs as therapeutic delivery carriers for cancer therapy. Findings from preclinical studies are primarily discussed, with early phase clinical trials reviewed. We hope to provide readers updated information on the development of EVs as cancer therapeutic targets or therapeutic carriers.

Indexed as

Drug CarriersMolecular Targeted TherapyAnimalsCell CommunicationCell-Derived MicroparticlesDrug Delivery SystemsDrug DevelopmentExosomesExtracellular VesiclesHumansNanoparticlesNeoplasmsDrug Carrierscancer therapeuticdrug carrierexosomeextracellular vesiclemicrovesicle

Identifiers

PMID32847103
PMCPMC7504131
OpenAlexW3080613967

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.