ReviewJournal of clinical medicine2020
Deep Brain Stimulation for Treatment-Resistant Depression: Towards a More Personalized Treatment Approach.
Review in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Cost-effectiveness and threshold analysis of deep brain stimulation vs. treatment-as-usual for treatment-resistant depression.Translational psychiatry · 2024Pooled it
- The ventral capsule and ventral striatum-Stereotactic targets for the management of treatment-resistant depression. A systematic literature review.Frontiers in psychiatry · 2023Pooled it
- Bridging the translational gap in systems neuroscience: from circuit mechanisms to clinical therapeutics.Frontiers in pharmacology · 2026Review
- Combinatorial effects of multi-site stimulation on depression-related brain regions: clinical data analysis and predictive modeling.Frontiers in psychiatry · 2026Article
- Innovative approaches in the treatment-resistant depression: exploring different therapeutic pathways.GeroScience · 2025Review
- Acute and chronic gene expression activation following medial forebrain bundle DBS and selective dopamine pathway stimulation.Scientific reports · 2025Article
- Affective bias predicts changes in depression during deep brain stimulation therapy.Frontiers in human neuroscience · 2025Article
- AKT/mTOR/BDNF pathway mediates the antidepressant-like effects of NAc-DBS in a mouse model of depression.Frontiers in behavioral neuroscience · 2025Article
- Article
- Linking connectivity of deep brain stimulation of nucleus accumbens area with clinical depression improvements: a retrospective longitudinal case series.European archives of psychiatry and clinical neuroscience · 2024Article
- Decoding Post-Viral Fatigue: The Basal Ganglia's Complex Role in Long-COVID.Neurology international · 2024Review
- Biohybrid neural interfaces: improving the biological integration of neural implants.Chemical communications (Cambridge, England) · 2023Review
- Magneto-responsive hyaluronan hydrogel for hyperthermia and bioprinting: Magnetic, rheological properties and biocompatibility.APL bioengineering · 2023Article
- Nucleus accumbens deep brain stimulation improves depressive-like behaviors through BDNF-mediated alterations in brain functional connectivity of dopaminergic pathway.Neurobiology of stress · 2023Article
- Article
- Aberrant Resting-State Functional Connectivity in MDD and the Antidepressant Treatment Effect-A 6-Month Follow-Up Study.Brain sciences · 2023Article
- Optimization of closed-loop electrical stimulation enables robust cerebellar-directed seizure control.Brain : a journal of neurology · 2023Article
- An open-label prospective pilot trial of nucleus accumbens deep brain stimulation for children with autism spectrum disorder and severe, refractory self-injurious behavior: study protocol.Pilot and feasibility studies · 2022Article
- Striatal networks for tinnitus treatment targeting.Human brain mapping · 2022Article
- Deep Brain Stimulation of the Nucleus Accumbens in Severe Enduring Anorexia Nervosa: A Pilot Study.Frontiers in behavioral neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major depressive disorder (MDD) affects approximately 4.4% of the world's population. One third of MDD patients do not respond to routine psychotherapeutic and pharmacotherapeutic treatment and are said to suffer from treatment-resistant depression (TRD). Deep brain stimulation (DBS) is increasingly being investigated as a treatment modality for TRD. Although early case studies showed promising results of DBS, open-label trials and placebo-controlled studies have reported inconsistent outcomes. This has raised discussion about the correct interpretation of trial results as well as the criteria for patient selection, the choice of stimulation target, and the optimal stimulation parameters. In this narrative review, we summarize recent studies of the effectiveness of DBS in TRD and address the relation between the targeted brain structures and clinical outcomes. Elaborating upon that, we hypothesize that the effectiveness of DBS in TRD can be increased by a more personalized and symptom-based approach. This may be achieved by using resting-state connectivity mapping for neurophysiological subtyping of TRD, by using individualized tractography to help decisions about stimulation target and electrode placement, and by using a more detailed registration of symptomatic improvements during DBS, for instance by using 'experience sampling' methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.