Evidence map›Paper›PMID 32846954›Full record

ArticleCells2020

IL-13 as Target to Reduce Cholestasis and Dysbiosis in

Luisa Hahn, Nora Helmrich, Diran Herebian, Ertan Mayatepek, Uta Drebber, Eugen Domann, Stefan Olejniczak, Markus Weigel, Torsten Hain, Timo Rath and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 8 institutions in 1 country.

Luisa HahnDepartment of Gastroenterology, Justus-Liebig-University, D-35392 Giessen, Germany.
Nora HelmrichDepartment of Gastroenterology, Justus-Liebig-University, D-35392 Giessen, Germany.
Diran HerebianDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, Heinrich-Heine-University, D-40225 Duesseldorf, Germany.ORCID 0000-0002-8528-0122
Ertan MayatepekDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, Heinrich-Heine-University, D-40225 Duesseldorf, Germany.ORCID 0000-0001-8460-3738
Uta DrebberInstitute for Pathology, University Hospital of Cologne, D-50937 Cologne, Germany.
Eugen DomannInstitute of Medical Microbiology, German Centre for Infection Research (DZIF Partner Site Giessen-Marburg-Langen), Justus-Liebig-University, D-35392 Giessen, Germany.
Stefan OlejniczakInstitute of Medical Microbiology, German Centre for Infection Research (DZIF Partner Site Giessen-Marburg-Langen), Justus-Liebig-University, D-35392 Giessen, Germany.
Markus WeigelInstitute of Medical Microbiology, German Centre for Infection Research (DZIF Partner Site Giessen-Marburg-Langen), Justus-Liebig-University, D-35392 Giessen, Germany.ORCID 0000-0002-3140-3174
Torsten HainInstitute of Medical Microbiology, German Centre for Infection Research (DZIF Partner Site Giessen-Marburg-Langen), Justus-Liebig-University, D-35392 Giessen, Germany.
Timo RathDepartment of Medicine 1, Division of Gastroenterology, Pneumology and Endocrinology, Friedrich-Alexander University Erlangen-Nuremberg, D-91054 Erlangen, Germany.
Stefan WirtzDepartment of Medicine 1, Division of Gastroenterology, Pneumology and Endocrinology, Friedrich-Alexander University Erlangen-Nuremberg, D-91054 Erlangen, Germany.
Hans-Joachim MollenkopfCore Facility Microarray, Max Planck Institute for Infection Biology, D-10117 Berlin, Germany.ORCID 0000-0003-1167-4783
Nadine SchmidtInstitute of Hygiene and Infectious Diseases of Animals, Justus-Liebig-University Giessen, D-35392 Giessen, Germany.
Christa EwersInstitute of Hygiene and Infectious Diseases of Animals, Justus-Liebig-University Giessen, D-35392 Giessen, Germany.
Anne BaierDepartment of Gastroenterology, Justus-Liebig-University, D-35392 Giessen, Germany.
Yuri ChurinDepartment of Gastroenterology, Justus-Liebig-University, D-35392 Giessen, Germany.
Anita WindhorstInstitute for Medical Informatics, Justus-Liebig-University, D-35392 Giessen, Germany.
Ralf WeiskirchenInstitute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), University Hospital, RWTH Aachen University, D-52074 Aachen, Germany.ORCID 0000-0003-3888-0931
Ulrich SteinhoffInstitute for Medical Microbiology and Hospital Hygiene, Philipps University Marburg, D-35043 Marburg, Germany.ORCID 0000-0003-2141-7756
Elke RoebDepartment of Gastroenterology, Justus-Liebig-University, D-35392 Giessen, Germany.
Martin RoderfeldDepartment of Gastroenterology, Justus-Liebig-University, D-35392 Giessen, Germany.ORCID 0000-0002-3232-1277
Justus-Liebig-Universität Gießen · DEGerman Center for Infection Research · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEHeinrich Heine University Düsseldorf · DEMax Planck Institute for Infection Biology · DEPhilipps University of Marburg · DERWTH Aachen University · DEUniversity Hospital Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Th2 cytokine IL-13 is involved in biliary epithelial injury and liver fibrosis in patients as well as in animal models. The aim of this study was to investigate IL-13 as a therapeutic target during short term and chronic intrahepatic cholestasis in an

Indexed as

AnimalsCholestasis, IntrahepaticDisease Models, AnimalDysbiosisHumansInterleukin-13MiceMice, KnockoutInterleukin-13bacterial translocationbile acidintestinal microbiomeliver fibrosisTh2tight junction

Identifiers

PMID32846954
PMCPMC7564366
OpenAlexW3081321868

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.