ArticleJournal of clinical medicine2020
Antimicrobial Effectiveness of Calcium Silicate Sealers against a Nutrient-Stressed Multispecies Biofilm.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Pooled it
- Exploring the Impact of Ultrasonic Activation on the Antimicrobial Activity of Root Canal Sealers: A Year-Long Ex Vivo Investigation Into Bacterial Survival.International endodontic journal · 2026Article
- Effect of Iron Oxide Nanoparticle Incorporation on the Cytocompatibility and Antimicrobial Behavior of a Calcium Silicate-Based Endodontic Sealer.Biomedicines · 2026Article
- Adverse tissue reaction to a next-generation bioceramic sealer: a structured literature review and case report.Frontiers in dental medicine · 2026Review
- Effect of powder particle size on hydration rates, permeability and antimicrobial properties of tricalcium silicate in root canals.Journal of materials science. Materials in medicine · 2025Article
- Multispecies Biofilms Treated With Endodontic Sealers or Calcium Hydroxide: Antimicrobial Activity and Changes in Community Composition.International endodontic journal · 2025Article
- Outcomes and prognostic factors of endodontically treated teeth filled with calcium silicate- or epoxy resin-based root canal sealers: A retrospective cohort study.International endodontic journal · 2025Article
- In Vitro Microscopical and Microbiological Assessment of the Sealing Ability of Calcium Silicate-Based Root Canal Sealers.Journal of functional biomaterials · 2024Article
- Biological properties versus solubility of endodontic sealers and cements.Biomaterial investigations in dentistry · 2024Review
- Interfacial adaptation of newly prepared nano-tricalcium silicate-58s bioactive glass-based endodontic sealer.Journal of dental research, dental clinics, dental prospects · 2024Article
- A critical review of the material properties guiding the clinician's choice of root canal sealers.Clinical oral investigations · 2023Review
- Fast-Setting Calcium Silicate-Based Pulp Capping Cements-Integrated Antibacterial, Irritation and Cytocompatibility Assessment.Materials (Basel, Switzerland) · 2023Article
- The dentine-sealer interface: Modulation of antimicrobial effects by irrigation.International endodontic journal · 2022Article
- Impacts of Resveratrol and Pyrogallol on Physicochemical, Mechanical and Biological Properties of Epoxy-Resin Sealers.Bioengineering (Basel, Switzerland) · 2022Article
- Antimicrobial and Antibiofilm Properties of Bioceramic Materials in Endodontics.Materials (Basel, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study compared the antimicrobial efficacy of calcium silicate sealers (BioRoot RCS and Total Fill BC) and conventional sealers (AH Plus and Tubli-seal) against planktonic bacteria and a nutrient-stressed multispecies biofilm.
methodsAntimicrobial properties of freshly mixed sealers were investigated using the direct contact test (DCT) and a nutrient-stressed multispecies biofilm comprised of five endodontic strains. Antimicrobial activity was determined using quantitative viable counts and confocal laser scanning microscopy (CLSM) analysis with live/dead staining. The pH of the sealers was analysed over a period of 28 days in Hanks Balanced Salt Solution (HBSS). Analysis of variance (ANOVA) with Tukey tests and the Kruskal-Wallis test were used for data analysis with a significance of 5%.
resultsAll endodontic sealers exhibited significant antimicrobial activity against planktonic bacteria (
conclusionsCalcium silicate sealers exhibited effective antimicrobial properties. This was demonstrated by superior biofilm inhibition capacity and microbial killing, with strong alkalizing activity compared to epoxy-based and zinc oxide-eugenol-based sealers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.