Evidence map›Paper›PMID 32846906›Full record

ReviewBiology2020

Immune Dysfunction and Multiple Treatment Modalities for the SARS-CoV-2 Pandemic: Races of Uncontrolled Running Sweat?

Ashish Kothari, Vanya Singh, Uttam Kumar Nath, Sandeep Kumar, Vineeta Rai, Karanvir Kaushal, Balram Ji Omar, Atul Pandey, Neeraj Jain

Open access · goldAbstract readReview
In one paragraph

Review in Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. An Eventual Sars-CoV-2 Infection Prevention Protocol in the Medical Setting and Dental Office.International journal of environmental research and public health · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Ashish KothariDepartment of Microbiology, All India Institute of Medical Sciences, Rishikesh 249203, India.
Vanya SinghDepartment of Microbiology, All India Institute of Medical Sciences, Rishikesh 249203, India.
Uttam Kumar NathDepartment of Medical Oncology & Hematology, All India Institute of Medical Sciences, Rishikesh 249203, India.
Sandeep KumarSchool of Medicine, Tulane University, New Orleans, LA 70112, USA.
Vineeta RaiDepartment of Entomology & Plant Pathology, North Carolina State University, Raleigh, NC 27695, USA.
Karanvir KaushalDepartment of Biochemistry, All India Institute of Medical Sciences, Rishikesh 249203, India.
Balram Ji OmarDepartment of Microbiology, All India Institute of Medical Sciences, Rishikesh 249203, India.ORCID 0000-0001-7805-2730
Atul PandeyDepartment of Ecology, Evolution and Behavior, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.ORCID 0000-0001-6954-6990
Neeraj JainDepartment of Medical Oncology & Hematology, All India Institute of Medical Sciences, Rishikesh 249203, India.ORCID 0000-0002-3736-8621
All India Institute of Medical Sciences Rishikesh · INHebrew University of Jerusalem · ILNorth Carolina State University · USTulane University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic threat with more than 11.8 million confirmed cases and more than 0.5 million deaths as of 3 July 2020. Given the lack of definitive pharmaceutical interventions against SARS-CoV-2, multiple therapeutic strategies and personal protective applications are being used to reduce the risk of high mortality and community spread of this infection. Currently, more than a hundred vaccines and/or alternative therapeutic regimens are in clinical trials, and some of them have shown promising results in improving the immune cell environment and controlling the infection. In this review, we discussed high-performance multi-directory strategies describing the uncontrolled deregulation of the host immune landscape associated with coronavirus disease (COVID-19) and treatment strategies using an anti-neoplastic regimen. We also followed selected current treatment plans and the most important on-going clinical trials and their respective outcomes for blocking SARS-CoV-2 pathogenesis through regenerative medicine, such as stem cell therapy, chimeric antigen receptors, natural killer (NK) cells, extracellular vesicular-based therapy, and others including immunomodulatory regimens, anti-neoplastic therapy, and current clinical vaccine therapy.

Indexed as

adoptive cell-based therapyanti-neoplastic regimenCOVID-19cytokine stormextracellular vesiclesimmunomodulatory drugsmesenchymal stem cells

Identifiers

PMID32846906
PMCPMC7563789
OpenAlexW3081200932

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.