Evidence map›Paper›PMID 32846776›Full record

Observational studyMedicine2020

Association of patterns of multimorbidity with length of stay: A multinational observational study.

Carole E Aubert, Jeffrey L Schnipper, Niklaus Fankhauser, Pedro Marques-Vidal, Jérôme Stirnemann, Andrew D Auerbach, Eyal Zimlichman, Sunil Kripalani, Eduard E Vasilevskis, Edmondo Robinson and 4 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 31 citations in OpenAlex.

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  7. Increasing medical complexity among inpatients in urology over time A comparative retrospective chart review.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 3 countries.

Carole E AubertDepartment of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.ORCID 0000-0001-8325-8784
Jeffrey L SchnipperBWH Hospitalist Service, Division of General Medicine, Brigham and Women's Hospital, Boston, MA.
Niklaus FankhauserCTU Bern, and Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Pedro Marques-VidalDivision of Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Jérôme StirnemannDepartment of Internal Medicine, Geneva University Hospital, Geneva, Switzerland.
Andrew D AuerbachDivision of Hospital Medicine, University of California, San Francisco, CA.
Eyal ZimlichmanSheba Medical Centre, Tel Hashomer, Israel.
Sunil KripalaniSection of Hospital Medicine, Division of General Internal Medicine and Public Health Vanderbilt University, Nashville, TN.
Eduard E VasilevskisSection of Hospital Medicine, Division of General Internal Medicine and Public Health Vanderbilt University, Nashville, TN.
Edmondo RobinsonChristiana Care Health System, Wilmington, DE.
Joshua MetlayDivision of General Internal Medicine, Massachusetts General Hospital, Boston, MA.
Grant S FletcherDepartment of Medicine, Harborview Medical Center, University of Washington, Seattle, WA.
Andreas LimacherCTU Bern, and Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Jacques DonzéHarvard Medical School, Boston, MA.
University of Bern · CHBrigham and Women's Hospital · USVanderbilt University · USChristiana Care Health System · USMassachusetts General Hospital · USSheba Medical Center · ILUniversity Hospital of Geneva · CHUniversity of California, San Francisco · USUniversity of Lausanne · CHUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to identify the combinations of chronic comorbidities associated with length of stay (LOS) among multimorbid medical inpatients.Multinational retrospective cohort of 126,828 medical inpatients with multimorbidity, defined as ≥2 chronic diseases (data collection: 2010-2011). We categorized the chronic diseases into comorbidities using the Clinical Classification Software. We described the 20 combinations of comorbidities with the strongest association with prolonged LOS, defined as longer than or equal to country-specific LOS, and reported the difference in median LOS for those combinations. We also assessed the association between the number of diseases or body systems involved and prolonged LOS.The strongest association with prolonged LOS (odds ratio [OR] 7.25, 95% confidence interval [CI] 6.64-7.91, P < 0.001) and the highest difference in median LOS (13 days, 95% CI 12.8-13.2, P < 0.001) were found for the combination of diseases of white blood cells and hematological malignancy. Other comorbidities found in the 20 top combinations had ORs between 2.37 and 3.65 (all with P < 0.001) and a difference in median LOS of 2 to 5 days (all with P < 0.001), and included mostly neurological disorders and chronic ulcer of skin. Prolonged LOS was associated with the number of chronic diseases and particularly with the number of body systems involved (≥7 body systems: OR 21.50, 95% CI 19.94-23.18, P < 0.001).LOS was strongly associated with specific combinations of comorbidities and particularly with the number of body systems involved. Describing patterns of multimorbidity associated with LOS may help hospitals anticipate resource utilization and judiciously allocate services to shorten LOS.

Indexed as

MultimorbidityAgedChronic DiseaseCohort StudiesFemaleHumansLength of StayMaleMiddle AgedRetrospective Studies

Identifiers

PMID32846776
PMCPMC7447409
OpenAlexW3069009830

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.