Evidence map›Paper›PMID 32846387›Full record

ArticleDevelopmental cognitive neuroscience2020

Reward-predictive cues elicit excessive reward seeking in adolescent rats.

Andrew T Marshall, Christy N Munson, Nigel T Maidment, Sean B Ostlund

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cognitive neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Dopamine Supports Reward Prediction to Shape Reward-Pursuit Strategy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Flexible control of Pavlovian-instrumental transfer based on expected reward value.Journal of experimental psychology. Animal learning and cognition · 2023
    Article
  6. Article
  7. Article
  8. Review
  9. Adolescent Dopamine Neurons Represent Reward Differently during Action and State Guided Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Andrew T MarshallDepartment of Anesthesiology and Perioperative Care, Irvine Center for Addiction Neuroscience, University of California, Irvine, Irvine, CA, United States. Electronic address: amarshall@chla.usc.edu.
Christy N MunsonDepartment of Anesthesiology and Perioperative Care, Irvine Center for Addiction Neuroscience, University of California, Irvine, Irvine, CA, United States.
Nigel T MaidmentDepartment of Psychiatry and Biobehavioral Sciences, Hatos Center for Neuropharmacology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, United States.
Sean B OstlundDepartment of Anesthesiology and Perioperative Care, Irvine Center for Addiction Neuroscience, University of California, Irvine, Irvine, CA, United States. Electronic address: sostlund@uci.edu.
University of California, Irvine · USUniversity of California, Los Angeles · US

Funding

Cholinergic regulation of striatal neurochemistry in cue-triggered decision-makingR01MH106972 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI OSTLUND, SEAN BJORN · 2016 to 2020
$2.5M
Neurochemical bases for changes in decision-making across the lifespanR01AG045380 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAIDMENT, NIGEL T, MURPHY, NIALL P · 2014 to 2018
$1.9M
NIA NIH HHS R01 AG045380NIMH NIH HHS R01 MH106972
6 · The paper itself

Abstract

Impulsive behavior during adolescence may stem from developmental imbalances between motivational and cognitive-control systems, producing greater urges to pursue reward and weakened capacities to inhibit such actions. Here, we developed a Pavlovian-instrumental transfer (PIT) protocol to assay rats' ability to suppress cue-motivated reward seeking based on changes in reward expectancy. Traditionally, PIT studies focus on how reward-predictive cues motivate instrumental reward-seeking behavior (lever pressing). However, cues signaling imminent reward delivery also elicit countervailing focal-search responses (food-port entry). We first examined how reward expectancy (cue-reward probability) influences expression of these competing behaviors. Adult male rats increased rates of lever pressing when presented with cues signaling lower probabilities of reward but focused their activity at the food cup on trials with cues that signaled higher probabilities of reward. We then compared adolescent and adult male rats in their responsivity to cues signaling different reward probabilities. In contrast to adults, adolescent rats did not flexibly adjust patterns of responding based on the expected likelihood of reward delivery but increased their rate of lever pressing for both weak and strong cues. These findings indicate that control over cue-motivated behavior is fundamentally dysregulated during adolescence, providing a model for studying neurobiological mechanisms of adolescent impulsivity.

Indexed as

RewardAnimalsConditioning, OperantCuesMaleMotivationRatsRats, Long-EvansAdolescenceImpulse controlMotivationPavlovian-instrumental transferRatsReward

Identifiers

PMID32846387
PMCPMC7451619
OpenAlexW3049000845

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.