ArticleDrug and alcohol dependence2020
Substance use disorders and risk of severe maternal morbidity in the United States.
Article in Drug and alcohol dependence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 63 citations in OpenAlex.
- Social determinants of health associated with newly documented opioid-related postpartum readmissions.Pregnancy (Hoboken, N.J.) · 2026Article
- Duration of Medication Use for Opioid Use Disorder and Risk of Postpartum Overdose and Death.JAMA network open · 2026Article
- Investigation of the impact of social, behavioral, and pre-existing clinical risk factors on preeclampsia.BMC pregnancy and childbirth · 2026Article
- Co-occurring opioid and stimulant use disorder and the relationship to severe maternal morbidity.Pregnancy (Hoboken, N.J.) · 2026Article
- Nursing Students' Knowledge, Attitudes, and Skills Related to Perinatal Substance Use.Substance use & addiction journal · 2026Article
- Trajectories of Medication Utilization for Opioid Use Disorder in Pregnancy and Associated Maternal Outcomes.O&G open · 2026Article
- Severe maternal morbidity in patients of advanced maternal age with and without metabolic syndrome.Archives of gynecology and obstetrics · 2026Article
- Adverse Pregnancy Outcomes with Co-Occurring Opioid and Stimulant Use Disorders.Journal of clinical medicine · 2026Article
- Maternal opioid use disorder and hepatitis C infection in pregnancy reshape the peripheral immune landscape at term.EBioMedicine · 2026Article
- Article
- Maternal Opioid-related Diagnosis in Pregnancy and Risk of Adverse Perinatal Outcomes.Journal of addiction medicine · 2025Article
- "I Feel Like a Lot of Black Women Don't Seek Preconception Health." Qualitative Findings of Preconception Health among Young Black Women in the United States.Journal of racial and ethnic health disparities · 2025Article
- Tobacco and cannabis use among pregnant women with prenatal opioid use.Addictive behaviors · 2025Article
- Multilevel Factors Associated With Hospitalizations in the First-Year Postpartum Among Persons With Opioid Use Disorder.Substance use & addiction journal · 2025Article
- Society for Maternal-Fetal Medicine Position Statement: Decriminalization of substance use disorder in pregnancy.Pregnancy (Hoboken, N.J.) · 2025Article
- Buprenorphine Treatment in Pregnancy and Maternal-Infant Outcomes.JAMA health forum · 2025Article
- Trends in and characteristics of drug overdose morbidity among pregnant and postpartum individuals in California, 2010-2018.American journal of epidemiology · 2025Article
- Severe Maternal Morbidity Among Pregnant People With Opioid Use Disorder Enrolled in Medicaid.JAMA network open · 2025Article
- Spatial Patterns of Delivery Hospitalizations with Opioid Use Disorder in Pennsylvania.Substance use & misuse · 2025Article
- Perceptions of substance use disorder in rural areas: how the brain disease model impacts public stigma.BMC public health · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe contribution of substance use disorders to the burden of severe maternal morbidity in the United States is poorly understood. The objective was to estimate the independent association between substance use disorders during pregnancy and risk of severe maternal morbidity.
methodsRetrospective analysis of a weighted 53.4 million delivery hospitalizations from 2003 to 2016 among females aged>18 in the National Inpatient Sample. We constructed measures of substance use disorders using diagnostic codes for cannabis, opioids, and stimulants (amphetamines or cocaine) abuse or dependence during pregnancy. The outcome was the presence of any of the 21 CDC indicators of severe maternal morbidity. Using weighted multivariable logistic regression, we estimated the association between substance use disorders and adjusted risk of severe maternal morbidity. Because older age at delivery is predictive of severe maternal morbidity, we tested for effect modification between substance use and maternal age by age group (18-34 y vs >34 y).
resultsPregnant women with an opioid use disorder had an increased risk of severe maternal morbidity compared with women without an opioid use disorder (18-34 years: aOR: 1.51; 95 % CI: 1.41,1.61, >34 years: aOR: 1.17; 95 % CI: 1.00,1.38). Compared with their counterparts without stimulant use disorders, pregnant women with a simulant use disorder (amphetamines, cocaine) had an increased risk of severe maternal morbidity (18-34 years: aOR: 1.92; 95 % CI: 1.80,2.0, >34 years: aOR: 1.85; 95 % CI: 1.66,2.06). Cannabis use disorders were not associated with an increased risk of severe maternal morbidity.
conclusionSubstance use disorders during pregnancy, particularly opioids, amphetamines, and cocaine use disorders, may contribute to severe maternal morbidity in the United States.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.