Evidence map›Paper›PMID 32846150›Full record

ReviewExperimental eye research2020

Nonlinear optical crosslinking (NLO CXL) for correcting refractive errors.

Samantha Bradford, Eric Mikula, Tibor Juhasz, Donald J Brown, James V Jester

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental eye research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Advances in the diagnosis and treatment of keratoconus.Therapeutic advances in ophthalmology
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Samantha BradfordDepartment of Ophthalmology and Biomedical Engineering, University of California, Irvine, Irvine, CA, United States. Electronic address: smbradfo@uci.edu.
Eric MikulaDepartment of Ophthalmology and Biomedical Engineering, University of California, Irvine, Irvine, CA, United States.
Tibor JuhaszDepartment of Ophthalmology and Biomedical Engineering, University of California, Irvine, Irvine, CA, United States.
Donald J BrownDepartment of Ophthalmology and Biomedical Engineering, University of California, Irvine, Irvine, CA, United States.
James V JesterDepartment of Ophthalmology and Biomedical Engineering, University of California, Irvine, Irvine, CA, United States.
University of California, Irvine · US

Funding

Non-linear Optical Collagen Cross-linking (NLO CXL) for Treatment of Keratoconus.R01EY024600 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI JESTER, JAMES V · 2014 to 2024
$3.1M
NEI NIH HHS R01 EY024600
6 · The paper itself

Abstract

Ultraviolet A (UVA) light-based photoactivation of riboflavin (Rf) to induce corneal crosslinking (CXL) and mechanical stiffening is now a well-known treatment for corneal ectasia and Keratoconus that is being used in a topographically guided photorefractive intrastromal CXL (PiXL) procedure to treat low degrees of refractive errors. Alternative approaches for non-invasive treatment of refractive errors have also been proposed that use femtosecond lasers (FS) that provide much faster, more precise, and safer results than UVA CXL. One such treatment, nonlinear optical crosslinking (NLO CXL), has been able to replicate the effects of UVA CXL, while producing a smaller area of cellular damage and requiring a shorter procedure time. Unlike UVA CXL, the treatment volume of NLO CXL only occurs within the focal volume of the laser, which can be placed at any depth and scanned into any pattern for true topographically guided refractive correction. This review presents our experience with using FS lasers to photoactivate Rf and perform highly controlled corneal CXL that leads to mechanical stiffening and changes in corneal shape.

Indexed as

CollagenCross-Linking ReagentsHumansKeratoconusPhotochemotherapyPhotosensitizing AgentsRefraction, OcularCollagenCross-Linking ReagentsPhotosensitizing AgentsCorneaCrosslinkingFemtosecond laserNonlinear

Identifiers

PMID32846150
PMCPMC7554135
OpenAlexW3081129353

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.