ArticleNeuron2020
Optimized Signal Flow through Photoreceptors Supports the High-Acuity Vision of Primates.
Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- High-Fidelity Backpropagation through Primate Foveal Cones.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- HIGH-FIDELITY BACKPROPAGATION THROUGH PRIMATE FOVEAL CONES.bioRxiv : the preprint server for biology · 2026Article
- Connectome of a human foveal retina.bioRxiv : the preprint server for biology · 2026Article
- Synchronization of visual perception within the human fovea.Nature neuroscience · 2025Article
- How the retina keeps the precise timing needed for coherent visual perception.Nature neuroscience · 2025Article
- Regional tuning of photoreceptor adaptation in the primate retina.Nature communications · 2024Article
- Evolutionary and developmental specialization of foveal cell types in the marmoset.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Encoding of environmental illumination by primate melanopsin neurons.Science (New York, N.Y.) · 2023Article
- T-Type CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Cone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea.Cell stem cell · 2022Article
- Temporal vision: measures, mechanisms and meaning.The Journal of experimental biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The fovea is a neural specialization that endows humans and other primates with the sharpest vision among mammals. This performance originates in the foveal cones, which are extremely narrow and long to form a high-resolution pixel array. Puzzlingly, this form is predicted to impede electrical conduction to an extent that appears incompatible with vision. We observe the opposite: signal flow through even the longest cones (0.4-mm axons) is essentially lossless. Unlike in most neurons, amplification and impulse generation by voltage-gated channels are dispensable. Rather, sparse channel activity preserves intracellular current, which flows as if unobstructed by organelles. Despite these optimizations, signaling would degrade if cones were lengthier. Because cellular packing requires that cone elongation accompanies foveal expansion, this degradation helps explain why the fovea is a constant, miniscule size despite multiplicative changes in eye size through evolution. These observations reveal how biophysical mechanisms tailor form-function relationships for primate behavioral performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.