ArticleCell reports2020
How Tasks Change Whole-Brain Functional Organization to Reveal Brain-Phenotype Relationships.
Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
- Precision Functional Parcellation of the Human Cortex via Rest-Task fMRI Fusion.bioRxiv : the preprint server for biology · 2026Article
- Using connectome-based predictive models to reveal the systems standardized tests and clinical symptoms are reflecting.Nature communications · 2026Article
- Task and Resting-State Functional Magnetic Resonance Imaging Modeling of Brain-Behavior Relationships in Developmental Cohorts.Biological psychiatry · 2026Review
- Trait-Relevant Tasks Improve Personality Prediction From Structural-Functional Brain Network Coupling.Human brain mapping · 2026Article
- Convergent and selective representations of pain, appetitive processes, aversive processes, and cognitive control in the insula.Nature communications · 2026Article
- Task-evoked functional connectivity exhibits novel and strengthened relationships with executive function relative to the resting state.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Optimizing functional connectivity scanning conditions for predicting autistic traits.medRxiv : the preprint server for health sciences · 2026Article
- Loneliness exacerbates age differences in the -allostatic-interoceptive system during induced affect.Social cognitive and affective neuroscience · 2026Article
- Optimizing functional connectivity scanning conditions for predicting autistic traits.Nature. Mental health · 2026Article
- Connectome caricatures remove large-amplitude coactivation patterns in resting-state fMRI to emphasize individual differences.Nature neuroscience · 2025Article
- Article
- Connectome-Based Predictive Models of General and Specific Executive Functions.Human brain mapping · 2025Article
- Trait-Relevant Tasks Improve Personality Prediction from Structural-Functional Brain Network Coupling.bioRxiv : the preprint server for biology · 2025Article
- A Transdiagnostic fMRI Dataset With 300+ Deeply Phenotyped Subjects Across Resting and Task States.medRxiv : the preprint server for health sciences · 2025Article
- Task-evoked functional connectivity exhibits novel and strengthened relationships with executive function relative to the resting state.bioRxiv : the preprint server for biology · 2025Article
- Structural-functional brain network coupling during cognitive demand reveals intelligence-relevant communication strategies.Communications biology · 2025Article
- Clinical response to neurofeedback in major depression relates to subtypes of whole-brain activation patterns during training.Molecular psychiatry · 2025Article
- Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors.JAMA network open · 2025Article
- Stimulus Selection Influences Prediction of Individual Phenotypes in Naturalistic Conditions.Human brain mapping · 2025Article
- Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Functional connectivity (FC) calculated from task fMRI data better reveals brain-phenotype relationships than rest-based FC, but how tasks have this effect is unknown. In over 700 individuals performing seven tasks, we use psychophysiological interaction (PPI) and predictive modeling analyses to demonstrate that task-induced changes in FC successfully predict phenotype, and these changes are not simply driven by task activation. Activation, however, is useful for prediction only if the in-scanner task is related to the predicted phenotype. To further characterize these predictive FC changes, we develop and apply an inter-subject PPI analysis. We find that moderate, but not high, task-induced consistency of the blood-oxygen-level-dependent (BOLD) signal across individuals is useful for prediction. Together, these findings demonstrate that in-scanner tasks have distributed, phenotypically relevant effects on brain functional organization, and they offer a framework to leverage both task activation and FC to reveal the neural bases of complex human traits, symptoms, and behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.