ArticleCancer medicine2020
Timing of fluorodeoxyglucose positron emission tomography maximum standardized uptake value for diagnosis of local recurrence of non-small cell lung cancer after stereotactic body radiation therapy.
Article in Cancer medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors at 1 institution in 1 country.
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Abstract
introductionAfter treatment with stereotactic body radiation therapy (SBRT), local recurrence of non-small cell cancer (NSCLC) can be difficult to differentiate from radiation-induced changes. Maximum standardized uptake value (SUVmax), measured with 18-F-Fluorodeoxyglucose positron emission tomography (FDG-PET), can have false positives due to acute radiation inflammation. The primary study objective was to determine the utility of SUVmax > 5 to identify local recurrence later than 9 months after SBRT.
methodA retrospective review was performed of FDG-PET scans for suspicious CT findings after SBRT treatment of stage 1 NSCLC. SUVmax was measured including surrounding opacification. Outcome measures were local recurrence, progression free survival, and overall survival. Receiver operator curve analysis, sensitivity, specificity, and Kaplan-Meier analysis were performed.
resultsOf 118 patients treated, 42 patients had eligible FDG-PET scans. They received SBRT (48-60Gy in 3-8 fractions) for 49 NSCLC and had 101 follow-up PET scans. The median time to first PET scan was 9.3 months, and the median follow-up period was 22.4 months. Local recurrence was diagnosed in 12 patients, at a median of 16 months. Due to selection bias, the included patients had poorer outcomes than the entire cohort, with progression free survival (PFS) at 1, 2, and 3 years of 82.7%, 57.8%, and 45.8%; and overall survival of 97.9%, 79.9%, and 59.1%, respectively. Thirty FDG-PET scans were performed within 9 months, of which 17% were false positives. A total of 71 FDG-PET scans were performed beyond 9 months, and the median SUVmax was significantly higher for patients with local recurrence (7.48 vs. 2.14, P < .0001). SUVmax > 5 has a sensitivity of 91% (95% CI 62%-99.8%) and 100% (89.1%-100%).
conclusionFor local recurrence of NSCLC, SUVmax > 5 on FDG-PET scan has good sensitivity and specificity after 6 months, but is highest beyond 9 months after SBRT.
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