ReviewJournal of thrombosis and haemostasis : JTH2020
COVID-19 coagulopathy in pregnancy: Critical review, preliminary recommendations, and ISTH registry-Communication from the ISTH SSC for Women's Health.
Review in Journal of thrombosis and haemostasis : JTH, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Thromboembolic risk in pregnant women with SARS-CoV-2 infection - A systematic review.Taiwanese journal of obstetrics & gynecology · 2022Pooled it
- Clinical care of pregnant and postpartum women with COVID-19: Living recommendations from the National COVID-19 Clinical Evidence Taskforce.The Australian & New Zealand journal of obstetrics & gynaecology · 2020Guideline
- Review
- Association between COVID-19 by variant period and delivery-related outcomes in the United States.PloS one · 2026Article
- Complex evaluation of coagulation, fibrinolysis, and inflammatory cytokines in SARS-CoV-2 infected pregnant women: a prospective, case-control study.Frontiers in immunology · 2025Observational
- Report of the ISTH registry on pregnancy and COVID-19-associated coagulopathy (COV-PREG-COAG).Obstetric medicine · 2024Article
- Lethal pulmonary embolism in a pregnant woman with severe acute respiratory syndrome coronavirus-2 receiving prophylactic anticoagulation: a case report.Journal of medical case reports · 2023Article
- Thromboprophylaxis in Pregnant Women with COVID-19: An Unsolved Issue.International journal of environmental research and public health · 2023Review
- Maternal and Neonatal Outcomes of COVID-19 Infection in Pregnancy.Archives of Iranian medicine · 2023Article
- Laboratory Testing of Hemostasis in Pregnancy: A Brief Overview.Methods in molecular biology (Clifton, N.J.) · 2023Review
- A review of COVID-19 therapeutics in pregnancy and lactation.Obstetric medicine · 2022Review
- A Review of Cardiovascular Complications among Pregnant Patients with COVID-19.Reviews in cardiovascular medicine · 2022Review
- Disseminated intravascular coagulation complicating mild or asymptomatic maternal COVID-19.AJOG global reports · 2022Article
- A Review of the Prevalence of Thromboembolic Complications among Pregnant Women Infected with COVID-19.Journal of clinical medicine · 2022Review
- Intrauterine fetal death during COVID-19 pregnancy: Typical fetal heart rate changes, coagulopathy, and placentitis.The journal of obstetrics and gynaecology research · 2022Article
- [COVID-19, pregnancy, anaesthesia and intensive care: Report and prospect].Le praticien en anesthesie reanimation · 2022Article
- D-dimer Levels in Predicting Severity of Infection and Outcome in Patients with COVID-19.Tanaffos · 2022Review
- Impact of COVID-19 on pregnant women in South Korea: Focusing on prevalence, severity, and clinical outcomes.Journal of infection and public health · 2022Article
- Psychological Impact of the COVID-19 Pandemic on Pregnant Women.Frontiers in pediatrics · 2022Article
- A Case Report of Severe Coagulopathy in Antenatal COVID-19.Case reports in obstetrics and gynecology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 8 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNovel coronavirus (SARS-CoV-2), which causes COVID-19, has thus far affected more than 15 million individuals, resulting in more than 600 000 deaths worldwide, and the number continues to rise. In a large systematic review and meta-analysis of the literature including 2567 pregnant women, 7% required intensive care admission, with a maternal mortality ~1% and perinatal mortality below 1%. There has been a rapid increase in publications on COVID-19-associated coagulopathy, including disseminated intravascular coagulopathy and venous thromboembolism, in the non-pregnant population, but very few reports of COVID-19 coagulopathy during pregnancy; leaving us with no guidance for care of this specific population.
methodsThis is a collaborative effort conducted by a group of experts that was reviewed, critiqued, and approved by the International Society on Thrombosis and Haemostasis Subcommittee for Women's Health Issues in Thrombosis and Hemostasis. A structured literature search was conducted, and the quality of current and emerging evidence was evaluated. Based on the published studies in the non-pregnant and pregnant population with a moderate to high risk of bias as assessed by Newcastle-Ottawa scale and acknowledging the absence of data from randomized clinical trials for management of pregnant women infected with SARS-CoV-2, a consensus in support of a guidance document for COVID-19 coagulopathy in pregnancy was identified. RESULTS AND
conclusionsSpecific hemostatic issues during pregnancy were highlighted, and preliminary recommendations to assist in the care of COVID-19-affected pregnant women with coagulopathy or thrombotic complications were developed. An international registry to gather data to support the management of COVID-19 and associated coagulopathy in pregnancy was established.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.