Evidence map›Paper›PMID 32846041›Full record

Trial reportMolecular nutrition & food research2020

Bilberry Supplementation after Myocardial Infarction Decreases Microvesicles in Blood and Affects Endothelial Vesiculation.

Paulina Bryl-Górecka, Ramasri Sathanoori, Lilith Arevström, Rikard Landberg, Cecilia Bergh, Mikael Evander, Björn Olde, Thomas Laurell, Ole Fröbert, David Erlinge

Open access · hybridAbstract readPragmatic Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Molecular nutrition & food research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Nutrients · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Paulina Bryl-GóreckaDepartment of Cardiology, Clinical Sciences, Lund University, 221 00, Lund, Sweden.ORCID 0000-0002-8173-1504
Ramasri SathanooriDepartment of Cardiology, Clinical Sciences, Lund University, 221 00, Lund, Sweden.
Lilith ArevströmFaculty of Health, Department of Cardiology, Örebro University, 702 81, Örebro, Sweden.
Rikard LandbergChalmers University of Technology, 412 96, Göteborg, Sweden.
Cecilia BerghClinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, 702 81, Örebro, Sweden.
Mikael EvanderDepartment of Biomedical Engineering, Lund University, 221 00, Lund, Sweden.
Björn OldeDepartment of Cardiology, Clinical Sciences, Lund University, 221 00, Lund, Sweden.
Thomas LaurellDepartment of Biomedical Engineering, Lund University, 221 00, Lund, Sweden.
Ole FröbertFaculty of Health, Department of Cardiology, Örebro University, 702 81, Örebro, Sweden.
David ErlingeDepartment of Cardiology, Clinical Sciences, Lund University, 221 00, Lund, Sweden.
Lund University · SEÖrebro University · SEChalmers University of Technology · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

scopeDiet rich in bilberries is considered cardioprotective, but the mechanisms of action are poorly understood. Cardiovascular disease is characterized by increased proatherogenic status and high levels of circulating microvesicles (MVs). In an open-label study patients with myocardial infarction receive an 8 week dietary supplementation with bilberry extract (BE). The effect of BE on patient MV levels and its influence on endothelial vesiculation in vitro is investigated. METHODS AND

resultsMVs are captured with acoustic trapping and platelet-derived MVs (PMVs), as well as endothelial-derived MVs (EMVs) are quantified with flow cytometry. The in vitro effect of BE on endothelial extracellular vesicle (EV) release is examined using endothelial cells and calcein staining. The mechanisms of BE influence on vesiculation pathways are studied by Western blot and qRT-PCR. Supplementation with BE decreased both PMVs and EMVs. Furthermore, BE reduced endothelial EV release, Akt phosphorylation, and vesiculation-related gene transcription. It also protects the cells from P2X

conclusionBE supplementation improves the MV profile in patient blood and reduces endothelial vesiculation through several molecular mechanisms related to the P2X

Indexed as

Dietary SupplementsExtracellular VesiclesVaccinium myrtillusAgedBlood PlateletsBlood ProteinsCell-Derived MicroparticlesEndothelial CellsFemaleGene ExpressionHematologic TestsHumansHuman Umbilical Vein Endothelial CellsMaleMyocardial InfarctionNanoparticlesBlood ProteinsP2RX7 protein, humanReceptors, Purinergic P2X7bilberriescardiovascular diseasesmicrovesiclesP2X7 (P2X purinoreceptor 7)

Identifiers

PMID32846041
PMCPMC7685140
OpenAlexW3080598446

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.