ArticlePloS one2020
Mathematically modeling spillovers of an emerging infectious zoonosis with an intermediate host.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Identifying host-specific patterns in viral protein sequences to predict host spillover risk in animal and plant kingdoms.Scientific reports · 2026Article
- Zoon0PredV: Potential Virus Species Crossover Prediction Using Convolutional Neural Networks and Viral Protein Sequence Patterns.Bioinformatics and biology insights · 2026Article
- Influence of natural and anthropogenic drivers on plague risk in Southwest China: A multicenter cross-sectional study.One health (Amsterdam, Netherlands) · 2025Article
- Impact of infectious diseases on wild bovidae populations in Thailand: insights from population modelling and disease dynamics.Journal of the Royal Society, Interface · 2024Article
- Modeling spillover dynamics: understanding emerging pathogens of public health concern.Scientific reports · 2024Article
- Population heterogeneity in vaccine coverage impacts epidemic thresholds and bifurcation dynamics.Heliyon · 2023Article
- Mathematical Modeling of SARS-CoV-2 Transmission between Minks and Humans Considering New Variants and Mink Culling.Tropical medicine and infectious disease · 2023Article
- Dynamics of Feline Coronavirus and FIP: A Compartmental Modeling Approach.Veterinary medicine international · 2023Article
- Human-Altered Landscapes and Climate to Predict Human Infectious Disease Hotspots.Tropical medicine and infectious disease · 2022Article
- Highly coordinated nationwide massive travel restrictions are central to effective mitigation and control of COVID-19 outbreaks in China.Proceedings. Mathematical, physical, and engineering sciences · 2022Article
- Article
- Implications of Glycosaminoglycans on Viral Zoonotic Diseases.Diseases (Basel, Switzerland) · 2021Review
- Application of a novel mathematical model to identify intermediate hosts of SARS-CoV-2.Journal of theoretical biology · 2021Article
- COVID-19 Spotlights Connections between Disease and Multiple Lifestyle Factors.American journal of lifestyle medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Modeling the behavior of zoonotic pandemic threats is a key component of their control. Many emerging zoonoses, such as SARS, Nipah, and Hendra, mutated from their wild type while circulating in an intermediate host population, usually a domestic species, to become more transmissible among humans, and this transmission route will only become more likely as agriculture and trade intensifies around the world. Passage through an intermediate host enables many otherwise rare diseases to become better adapted to humans, and so understanding this process with accurate mathematical models is necessary to prevent epidemics of emerging zoonoses, guide policy interventions in public health, and predict the behavior of an epidemic. In this paper, we account for a zoonotic disease mutating in an intermediate host by introducing a new mathematical model for disease transmission among three species. We present a model of these disease dynamics, including the equilibria of the system and the basic reproductive number of the pathogen, finding that in the presence of biologically realistic interspecies transmission parameters, a zoonotic disease with the capacity to mutate in an intermediate host population can establish itself in humans even if its R0 in humans is less than 1. This result and model can be used to predict the behavior of any zoonosis with an intermediate host and assist efforts to protect public health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.