ArticlePLoS genetics2020
Demographic history shaped geographical patterns of deleterious mutation load in a broadly distributed Pacific Salmon.
Article in PLoS genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- EliminatingInsects · 2026Article
- The Effects of Latitudinal Gradients, Climatic Anomalies, and Size-Selective Harvesting on the Adaptive Potential of an Intertidal Gastropod.Evolutionary applications · 2025Article
- Mutational load and adaptive variation are shaped by climate and species range dynamics in Vitis arizonica.The New phytologist · 2025Article
- Article
- Revealing the evolutionary history and contemporary population structure of Pacific salmon in the Fraser River through genome resequencing.G3 (Bethesda, Md.) · 2024Article
- Allele surfing causes maladaptation in a Pacific salmon of conservation concern.PLoS genetics · 2023Article
- Unraveling Prevalence and Effects of Deleterious Mutations in Maize Elite Lines across Decades of Modern Breeding.Molecular biology and evolution · 2023Article
- Population-size history inferences from the coho salmon (Oncorhynchus kisutch) genome.G3 (Bethesda, Md.) · 2023Article
- Deleterious Variation in Natural Populations and Implications for Conservation Genetics.Annual review of animal biosciences · 2023Review
- High-density genomic data reveal fine-scale population structure and pronounced islands of adaptive divergence in lake whitefish (Evolutionary applications · 2022Article
- Re-evaluating Coho salmon (Evolutionary applications · 2022Article
- Population genetics reveals divergent lineages and ongoing hybridization in a declining migratory fish species complex.Heredity · 2022Article
- Article
- Article
- Landscape and Climatic Variations Shaped Secondary Contacts amid Barn Owls of the Western Palearctic.Molecular biology and evolution · 2022Article
- Genomic and environmental influences on resilience in a cold-water fish near the edge of its range.Evolutionary applications · 2021Article
- Hierarchical genetic structure and implications for conservation of the world's largest salmonid, Hucho taimen.Scientific reports · 2021Article
- Genomic methods reveal independent demographic histories despite strong morphological conservatism in fish species.Heredity · 2021Article
- Genomic data support management of anadromous Arctic Char fisheries in Nunavik by highlighting neutral and putatively adaptive genetic variation.Evolutionary applications · 2021Article
- Biases in Demographic Modeling Affect Our Understanding of Recent Divergence.Molecular biology and evolution · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A thorough reconstruction of historical processes is essential for a comprehensive understanding of the mechanisms shaping patterns of genetic diversity. Indeed, past and current conditions influencing effective population size have important evolutionary implications for the efficacy of selection, increased accumulation of deleterious mutations, and loss of adaptive potential. Here, we gather extensive genome-wide data that represent the extant diversity of the Coho salmon (Oncorhynchus kisutch) to address two objectives. We demonstrate that a single glacial refugium is the source of most of the present-day genetic diversity, with detectable inputs from a putative secondary micro-refugium. We found statistical support for a scenario whereby ancestral populations located south of the ice sheets expanded recently, swamping out most of the diversity from other putative micro-refugia. Demographic inferences revealed that genetic diversity was also affected by linked selection in large parts of the genome. Moreover, we demonstrate that the recent demographic history of this species generated regional differences in the load of deleterious mutations among populations, a finding that mirrors recent results from human populations and provides increased support for models of expansion load. We propose that insights from these historical inferences should be better integrated in conservation planning of wild organisms, which currently focuses largely on neutral genetic diversity and local adaptation, with the role of potentially maladaptive variation being generally ignored.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.