Evidence map›Paper›PMID 32845644›Full record

ArticleNano letters2020

Targeted Radiosensitizers for MR-Guided Radiation Therapy of Prostate Cancer.

Dong Luo, Andrew Johnson, Xinning Wang, Hao Li, Bernadette O Erokwu, Sarah Springer, Jason Lou, Gopalakrishnan Ramamurthy, Chris A Flask, Clemens Burda and 2 more

Open access · greenAbstract read
In one paragraph

Article in Nano letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 59 citations in OpenAlex.

  1. Review
  2. Article
  3. State-of-the-art application of nanoparticles in radiotherapy: a platform for synergistic effects in cancer treatment.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025
    Review
  4. Article
  5. Current Research in Drug-Free Cancer Therapies.Bioengineering (Basel, Switzerland) · 2025
    Review
  6. Review
  7. Applications of AuNanomaterials (Basel, Switzerland) · 2024
    Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Current applications of nanomaterials in urinary system tumors.Frontiers in bioengineering and biotechnology · 2023
    Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Dong LuoDepartment of Radiology, Case Western Reserve University, Cleveland, Ohio 44106, United States.ORCID 0000-0002-9711-2070
Andrew JohnsonDepartment of Chemistry, Molecular Biosciences, Neurobiology, and Radiology, Northwestern University, Evanston, Illinois 60208, United States.
Xinning WangDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Hao LiDepartment of Chemistry, Molecular Biosciences, Neurobiology, and Radiology, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0001-5444-1168
Bernadette O ErokwuDepartment of Radiology, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Sarah SpringerDepartment of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Jason LouDepartment of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Gopalakrishnan RamamurthyDepartment of Radiology, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Chris A FlaskDepartment of Radiology, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Clemens BurdaDepartment of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, United States.ORCID 0000-0002-7342-2840
Thomas J MeadeDepartment of Chemistry, Molecular Biosciences, Neurobiology, and Radiology, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0001-6202-1155
James P BasilionDepartment of Radiology, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Case Western Reserve University · USNorthwestern University · US

Funding

Theranostic gold nanoparticles for imaged-guided radical prostatectomy and PDT ablationR01EB020353 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI BASILION, JAMES PETER · 2016 to 2019
$2.7M
PSMA-targeted AuNPs for MR guided radiotherapy and radiosensitizationR01CA260847 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI AYDOGAN, BULENT, BASILION, JAMES PETER · 2021 to 2024
$2.6M
q-Modulated Magnetic Resonance Imaging Contrast AgentsR01EB005866 · NIBIB · NORTHWESTERN UNIVERSITY · PI MEADE, THOMAS J · 2005 to 2013
$2.2M
NCI NIH HHS R01 CA260847NIBIB NIH HHS R01 EB005866NIBIB NIH HHS R01 EB020353
6 · The paper itself

Abstract

Adjuvant radiotherapy is frequently prescribed to treat cancer. To minimize radiation-related damage to healthy tissue, it requires high precision in tumor localization and radiation dose delivery. This can be achieved by MR guidance and targeted amplification of radiation dose selectively to tumors by using radiosensitizers. Here, we demonstrate prostate cancer-targeted gold nanoparticles (AuNPs) for MR-guided radiotherapy to improve the targeting precision and efficacy. By conjugating Gd(III) complexes and prostate-specific membrane antigen (PSMA) targeting ligands to AuNP surfaces, we found enhanced uptake of AuNPs by PSMA-expressing cancer cells with excellent MR contrast and radiation therapy outcome

Indexed as

Metal NanoparticlesProstatic NeoplasmsCell Line, TumorGoldHumansMaleGoldMR-guided radiotherapynanoparticlesprostate cancerPSMA targetingRadiosensitizer

Identifiers

PMID32845644
PMCPMC9109254
OpenAlexW3080695461

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.