Evidence map›Paper›PMID 32845472›Full record

ReviewAdvances in therapy2020

Folic Acid Supplementation in Patients with Elevated Homocysteine Levels.

Alan D Kaye, George M Jeha, Alex D Pham, Mitchell C Fuller, Zachary I Lerner, Gerald T Sibley, Elyse M Cornett, Ivan Urits, Omar Viswanath, Christopher G Kevil

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 5 pooled it
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 5 syntheses or guidelines pooled it, 150 citations in OpenAlex.

  1. Pooled it
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  6. Trial
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  8. Article
  9. Review
  10. Foods (Basel, Switzerland) · 2026
    Article
  11. Article
  12. Review
  13. Review
  14. Homocysteine increases phosphorylation and aggregation of α-synuclein.Journal of clinical biochemistry and nutrition · 2026
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Alan D KayeDepartment of Pharmacology, Toxicology, and Neuroscience, LSU Health Shreveport, Shreveport, LA, USA.
George M JehaDepartment of Anesthesiology, LSU School of Medicine, LSU Health Sciences Center, New Orleans, LA, USA.
Alex D PhamDepartment of Anesthesiology, LSU Health New Orleans, New Orleans, LA, USA.
Mitchell C FullerMedical College of Wisconsin, Wauwatosa, WI, USA.
Zachary I LernerDepartment of Anesthesiology, LSU Health New Orleans, New Orleans, LA, USA.
Gerald T SibleyDepartment of Anesthesiology, LSU Health New Orleans, New Orleans, LA, USA.
Elyse M CornettDepartment of Anesthesiology, LSU Health Shreveport, Shreveport, LA, USA. ecorne@lsuhsc.edu.
Ivan UritsDepartment of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Omar ViswanathDepartment of Anesthesiology, LSU Health Shreveport, Shreveport, LA, USA.
Christopher G KevilDepartment of Pathology, LSU Health Shreveport, Shreveport, LA, USA.
Louisiana State University Health Sciences Center New Orleans · USLouisiana State University Health Sciences Center Shreveport · USBeth Israel Deaconess Medical Center · USMedical College of Wisconsin · US

Funding

Stress Exacerbates Myocardial Ischemic Injury by Blocking Estrogen's Antidoxidant Protection in the Female HeartP20GM121307 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI Christopher G Kevil · 2018 to 2026
$23.6M
CSE regulation of vascular remodelingR01HL149264 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI KEVIL, CHRISTOPHER G · 2020 to 2023
$1.7M
NHLBI NIH HHS R01 HL149264NIGMS NIH HHS P20 GM121307
6 · The paper itself

Abstract

introductionFolic acid is the most important dietary determinant of homocysteine (Hcy). Hcy serves as a critical intermediate in methylation reactions. It is created from methionine and either converted back to methionine or transformed into cysteine. This process is aided through several enzymes and three vitamins, folic acid, B12, and B6. Daily supplementation with 0.5-5.0 mg of folic acid typically lowers plasma Hcy levels by approximately 25%. Hyperhomocysteinemia is a known risk factor for coronary artery disease. In this regard, elevated levels of Hcy have been found in a majority of patients with vascular disease.

methodsA literature review of folic acid supplementation for various disease states including cardiovascular disease was conducted. This article is based on previously conducted studies and does not contain any studies with human participants or animals performed by any of the authors.

resultsIn this review, we discuss the biochemistry of folic acid, Hcy biosynthesis, Hcy and hydrogen sulfide bioavailability, pathogenesis of hyperhomocysteinemia and its role as a risk factor for disease, and treatment studies with folic acid supplementation in disease states.

conclusionFolic acid supplementation should be recommended to any patient who has an elevated Hcy level, and this level should be measured and treated at an early age, since folic acid is easily obtained and may likely reduce vascular disease and other deleterious pathologic processes in high-risk populations.

Indexed as

Folic AcidHyperhomocysteinemiaAnimalsDietary SupplementsHomocysteineHumansRisk FactorsFolic AcidHomocysteineCoronary artery diseaseFolic acidHeart diseaseHomocysteineHyperhomocysteinemia

Identifiers

PMID32845472
PMCPMC7497502
OpenAlexW3080644038

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.