Evidence map›Paper›PMID 32845464›Full record

ReviewCurrent osteoporosis reports2020

Bone-Specific Drug Delivery for Osteoporosis and Rare Skeletal Disorders.

Kazuki Sawamoto, J Víctor Álvarez, Angélica María Herreño, Francisco J Otero-Espinar, Maria L Couce, Carlos J Alméciga-Díaz, Shunji Tomatsu

Open access · greenAbstract readReview
In one paragraph

Review in Current osteoporosis reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. In and outside the spotlight: Nanomedicine in the treatment of osteoporosis.The Journal of international medical research · 2025
    Review
  2. Research progress of DUB enzyme in breast cancer.Clinical and experimental medicine · 2025
    Review
  3. Evaluation ofInternational journal of molecular sciences · 2025
    Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 4 countries.

Kazuki SawamotoNemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA.
J Víctor ÁlvarezNemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA.
Angélica María HerreñoNemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA.
Francisco J Otero-EspinarDepartment of Pharmacology, Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Santiago de Compostela, Santiago de Compostela, Spain.
Maria L CouceDepartment of CC Foren. An. Pat, Gin. and Obst. and Paed. Neonatology Service, Metabolic Unit, University Clinic Hospital of Santiago de Compostela, Santiago de Compostela, Spain.
Carlos J Alméciga-DíazInstitute for the Study of Inborn Errors of Metabolism, Faculty of Science, Pontificia Universidad Javeriana, Bogotá DC, Colombia.
Shunji TomatsuNemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA. stomatsu@nemours.org.ORCID 0000-0002-0673-2160
Alfred I. duPont Hospital for Children · USUniversidade de Santiago de Compostela · ESPontificia Universidad Javeriana · CO

Funding

Center for Pediatric ResearchP20GM103464 · NIGMS · NEMOURS CHILDREN'S HOSPITAL, DELAWARE · PI SHAFFER, THOMAS H · 2012 to 2014
$5.6M
Center for Pediatric Research Pilot ProgramP30GM114736 · NIGMS · NEMOURS CHILDREN'S HOSPITAL, DELAWARE · PI SHAFFER, THOMAS H · 2015 to 2019
$5.1M
NIGMS NIH HHS P20 GM103464NIGMS NIH HHS P30 GM114736
6 · The paper itself

Abstract

purpose of reviewThe skeletal system provides an important role to support body structure and protect organs. The complexity of its architecture and components makes it challenging to deliver the right amount of the drug into bone regions, particularly avascular cartilage lesions. In this review, we describe the recent advance of bone-targeting methods using bisphosphonates, polymeric oligopeptides, and nanoparticles on osteoporosis and rare skeletal diseases. RECENT

findingsHydroxyapatite (HA), a calcium phosphate with the formula Ca

Indexed as

Alkaline PhosphataseAmino Acids, AcidicBone Density Conservation AgentsBone DiseasesCalcitoninChondroitinsulfatasesDiphosphonatesDrug Delivery SystemsDurapatiteEnzyme Replacement TherapyHumansHypophosphatasiaMucopolysaccharidosis IVNanoparticlesOligopeptidesOsteoporosisAlkaline PhosphataseALPL protein, humanAmino Acids, AcidicBone Density Conservation AgentsCalcitoninChondroitinsulfatasesDiphosphonatesDurapatiteGALNS protein, humanOligopeptidesParathyroid HormoneAcidic amino acid oligopeptideBone-targetingMetabolic rare skeletal disordersNanoparticlesOsteoporosis

Identifiers

PMID32845464
PMCPMC7541793
OpenAlexW3080412916

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.