ArticleFEMS microbiology ecology2020
Mucoidy, a general mechanism for maintaining lytic phage in populations of bacteria.
Article in FEMS microbiology ecology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Article
- Cross-reactive anti-prophage antibodies and bacterial heteroresistance implicated in phage therapeutic failure.Nature medicine · 2026Article
- The intestinal environment potentiates bacteriophage adaptation in response to phenotypic resistance inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- At what cost? The impact of bacteriophage resistance on the growth kinetics and protein synthesis of Escherichia coli.Environmental microbiology reports · 2024Article
- Symbiosis of a lytic bacteriophage andApplied and environmental microbiology · 2024Article
- A tradeoff between bacteriophage resistance and bacterial motility is mediated by the Rcs phosphorelay inMicrobiology (Reading, England) · 2024Article
- Improving phage therapy by evasion of phage resistance mechanisms.JAC-antimicrobial resistance · 2024Review
- Article
- Experimental Evolution of the TolC-Receptor Phage U136B Functionally Identifies a Tail Fiber Protein Involved in Adsorption through Strong Parallel Adaptation.Applied and environmental microbiology · 2023Article
- Inhaled Bacteriophage Therapy for Multi-Drug ResistantThe Yale journal of biology and medicine · 2022Article
- Population Dynamics of a Two Phages-One Host Infection System UsingPharmaceuticals (Basel, Switzerland) · 2022Article
- Article
- Phenotypic flux: The role of physiology in explaining the conundrum of bacterial persistence amid phage attack.Virus evolution · 2022Review
- Article
- Article
- In Vitro Newly Isolated Environmental Phage Activity against Biofilms Preformed byMicroorganisms · 2021Article
- Prophage Activation in the Intestine: Insights Into Functions and Possible Applications.Frontiers in microbiology · 2021Review
- High-throughput mapping of the phage resistance landscape in E. coli.PLoS biology · 2020Article
- Biofilm Structure Promotes Coexistence of Phage-Resistant and Phage-Susceptible Bacteria.mSystems · 2020Article
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Authors and funding
7 authors.
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Abstract
We present evidence that phage resistance resulting from overproduction of exopolysaccharides, mucoidy, provides a general answer to the longstanding question of how lytic viruses are maintained in populations dominated by bacteria upon which they cannot replicate. In serial transfer culture, populations of mucoid Escherichia coli MG1655 that are resistant to lytic phages with different receptors, and thereby requiring independent mutations for surface resistance, are capable of maintaining these phages with little effect on their total density. Based on the results of our analysis of a mathematical model, we postulate that the maintenance of phage in populations dominated by mucoid cells can be attributed primarily to high rates of transition from the resistant mucoid states to susceptible non-mucoid states. Our tests with both population dynamic and single cell experiments as well as genomic analysis are consistent with this hypothesis. We discuss reasons for the generalized resistance of these mucoid E. coli, and the genetic and molecular mechanisms responsible for the high rate of transition from mucoid to sensitive states responsible for the maintenance of lytic phage in mucoid populations of E. coli.
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